{"id":"W2052590920","doi":"10.4161/onci.1.1.17824","title":"PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy","year":2012,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis; Rosetrees Trust","keywords":"Cytotoxic T cell; Immunotherapy; T-cell receptor; Effector; Ligand (biochemistry); Downregulation and upregulation; Stimulation; Cancer research; Co-stimulation; Function (biology); Antigen presentation; Cell biology; Chemistry; Receptor; T cell; Immunology; Medicine; Immune system; Biology; Neuroscience; Biochemistry; CD28; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396772,0.0003490163,0.000393152,0.000276604,0.0001822811,0.00082544,0.0004045779,0.0006558817,0.001600217],"category_scores_gemma":[0.0003066574,0.0002039097,0.0002308454,0.0002415225,0.0003551015,0.0005124049,0.0003694381,0.001271653,0.0005346325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000314456,"about_ca_system_score_gemma":0.0002286588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009527117,"about_ca_topic_score_gemma":0.0001770411,"domain_scores_codex":[0.9994925,0.0001315459,0.00004236825,0.00007578023,0.0001175934,0.0001400565],"domain_scores_gemma":[0.9998626,0.00004205065,0.000040834,0.00002096033,0.000008724461,0.00002477936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008808505,0.0003881426,0.0007179981,0.0003565902,0.00003050306,0.0003183337,0.0000404622,0.0004515472,0.9765189,0.001546864,0.0005295762,0.01822013],"study_design_scores_gemma":[0.0001050798,0.0008415267,0.003989751,0.00002173912,0.00003587719,0.001163313,0.00003758075,0.002239828,0.9823627,0.0005763922,0.008616908,0.000009358623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969466,0.01945909,0.0045417,0.0006394772,0.0002164913,0.00006340068,0.0001387061,0.0001284251,0.005346742],"genre_scores_gemma":[0.9937611,0.00242942,0.0008866583,0.0001972979,0.00007279821,0.00004420541,0.0001626069,0.00001404957,0.002431723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600217,"threshold_uncertainty_score":0.005353212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232872338531743,"score_gpt":0.3089287675875588,"score_spread":0.2866000442022414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}