{"id":"W2052617539","doi":"10.1126/science.1220967","title":"Whole-Genome Sequencing: The New Standard of Care?","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Genome; Computational biology; Whole genome sequencing; Biology; Evolutionary biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001835803,0.00004821189,0.00004793633,0.00001702745,0.0001020167,0.00001557646,0.0002991875,0.00001926467,0.000009101102],"category_scores_gemma":[0.00005048477,0.00003137659,0.00003515935,0.0001116484,0.0002623316,0.000004302104,0.000109664,0.00002169809,0.000006132106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001883294,"about_ca_system_score_gemma":0.0004780832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000851495,"about_ca_topic_score_gemma":0.000005859101,"domain_scores_codex":[0.9994735,0.000008184831,0.0000681839,0.0001186608,0.0001376552,0.0001938052],"domain_scores_gemma":[0.9995252,0.000002666204,0.00003495722,0.000255545,0.00007483068,0.0001067759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001089576,0.000003774133,0.0009841955,0.000003953613,0.000002521112,1.856553e-7,0.0004014336,0.00003227143,0.9975379,0.0001903349,0.0001882582,0.0006442598],"study_design_scores_gemma":[0.0001746297,0.000217903,0.01887212,0.000005774642,0.00001380965,0.00001264116,0.00172037,0.000002930711,0.6680007,0.0001507469,0.3106857,0.0001426481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925684,0.005037855,0.000253337,0.000152201,0.0001732116,0.00006777677,0.00003853704,0.000002573913,0.001706045],"genre_scores_gemma":[0.9991506,0.00003690406,0.0003013704,0.0001162425,0.0001401454,0.000001230008,0.000008872046,0.000003584905,0.0002411056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3295372,"threshold_uncertainty_score":0.12795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125850180934129,"score_gpt":0.2553596148538899,"score_spread":0.2441011130445486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}