{"id":"W2052620131","doi":"10.1038/srep06644","title":"Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency; Public Health Agency of Canada","keywords":"Transduction (biophysics); Biology; Transgene; Tissue tropism; Tropism; Virology; Adeno-associated virus; Virus; Gene; Genetic enhancement; Epitope; Genetically modified mouse; Computational biology; Molecular biology; Cell biology; Genetics; Recombinant DNA; Antibody; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006000738,0.0006140481,0.0003499907,0.0006744524,0.0002454465,0.000474117,0.00046678,0.0007779181,0.003388917],"category_scores_gemma":[0.000267591,0.0003730726,0.0005906769,0.0001644477,0.0004810736,0.0005633883,0.0003620531,0.001533235,0.001763879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059591,"about_ca_system_score_gemma":0.0002913839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002458554,"about_ca_topic_score_gemma":0.0004277356,"domain_scores_codex":[0.9996772,0.00005738856,0.0000374413,0.000101795,0.00005981847,0.00006646175],"domain_scores_gemma":[0.9997943,0.00004913747,0.00004928084,0.00003760615,0.00002007617,0.00004970995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359241,0.0000642115,0.0002166665,0.00009366297,0.00001128172,0.00009571556,0.00005359375,0.00006391372,0.9925982,0.0007988694,0.0002187527,0.005649246],"study_design_scores_gemma":[0.0001544526,0.002338168,0.005704772,0.0001005762,0.00009181042,0.001643777,0.00007509695,0.001549816,0.9199212,0.00081289,0.06758038,0.00002711797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7780203,0.007509378,0.179065,0.001082307,0.001250532,0.001433926,0.004509879,0.002019349,0.02510939],"genre_scores_gemma":[0.8164451,0.008493718,0.1104191,0.0010068,0.0002570368,0.00162378,0.01189126,0.000695084,0.04916803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003388917,"threshold_uncertainty_score":0.01133704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870879509114615,"score_gpt":0.2825347139765375,"score_spread":0.2638259188853913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}