{"id":"W2052620131","doi":"10.1038/srep06644","title":"Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency; Public Health Agency of Canada","keywords":"Transduction (biophysics); Biology; Transgene; Tissue tropism; Tropism; Virology; Adeno-associated virus; Virus; Gene; Genetic enhancement; Epitope; Genetically modified mouse; Computational biology; Molecular biology; Cell biology; Genetics; Recombinant DNA; Antibody; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00125049,0.0002024021,0.0002288727,0.0001240308,0.0001845745,0.0001593332,0.0003135474,0.000191131,0.0001888074],"category_scores_gemma":[0.0004256978,0.0002013327,0.00007867745,0.0004660263,0.0002406165,0.00001058732,0.00008867256,0.0001438849,0.00003652304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004295883,"about_ca_system_score_gemma":0.0002294094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006025479,"about_ca_topic_score_gemma":0.008162901,"domain_scores_codex":[0.9974887,0.0001466715,0.0004495928,0.000994314,0.0004459966,0.0004747719],"domain_scores_gemma":[0.99865,0.00002959381,0.0001695894,0.0008199998,0.0001868208,0.0001440548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000133873,0.0001715558,0.002949935,0.000005499223,0.00004157924,0.00003424893,0.0002651732,0.0000505875,0.9937951,9.399444e-7,0.001609336,0.0009421749],"study_design_scores_gemma":[0.0005393415,0.0002326682,0.002720964,0.00002418908,0.00001308721,0.00001617439,0.00007059962,0.00006524728,0.9829509,0.0002304609,0.01289293,0.0002434502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971119,0.0005492653,0.0004588622,0.0001579188,0.001085495,0.000276375,0.00003452321,0.00003178598,0.0002938815],"genre_scores_gemma":[0.9973102,0.00001779805,0.0003160381,0.000184544,0.0001259096,0.00002533887,0.0004562813,0.00004161708,0.001522288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0112836,"threshold_uncertainty_score":0.8210108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870879509114615,"score_gpt":0.2825347139765375,"score_spread":0.2638259188853913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}