{"id":"W2052667955","doi":"10.1021/jp905965h","title":"Structural Constraints Imposed by the Conserved Fusion Peptide on the HIV-1 gp41 Epitope Recognized by the Broadly Neutralizing Antibody 2F5","year":2009,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Epitope; Gp41; Peptide; Chemistry; Conformational isomerism; Circular dichroism; Sequence (biology); Peptide sequence; Helix (gastropod); Linear epitope; Protein structure; Crystallography; Stereochemistry; Antibody; Biophysics; Biology; Biochemistry; Molecule; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009514879,0.0001918723,0.00014883,0.0001009894,0.0001437148,0.000215576,0.0001502414,0.0002223205,0.0004189276],"category_scores_gemma":[0.0001749913,0.0001205749,0.0001291375,0.0000677541,0.0002370824,0.0001727296,0.0001585821,0.0004033037,0.0001193232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002042156,"about_ca_system_score_gemma":0.0001390236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005474386,"about_ca_topic_score_gemma":0.0007790133,"domain_scores_codex":[0.9998928,0.00001930906,0.000005613666,0.00001690885,0.00003453263,0.00003071801],"domain_scores_gemma":[0.9999124,0.00002617023,0.00002937175,0.000006416925,0.00000790867,0.00001789092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006655748,0.000007427045,0.0005754643,0.000009262626,0.000003635393,0.00005648595,0.000009930801,0.0003330643,0.9984567,0.00005623119,0.00000570186,0.0004194748],"study_design_scores_gemma":[0.00003361777,0.0005056325,0.04038335,0.00001146638,0.00003761487,0.0008854523,0.0001184201,0.005732262,0.9509466,0.000203443,0.001122399,0.00001969155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993685,0.0001013884,0.000305141,0.00000610751,0.000001239501,0.000001458462,0.00001895172,0.000002952979,0.0001943983],"genre_scores_gemma":[0.9992363,0.00006842982,0.0005186649,0.000019946,0.00000127582,0.000002327318,0.00007918355,0.000002724842,0.00007115413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005474386,"threshold_uncertainty_score":0.001481712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437336147793148,"score_gpt":0.2896258564816779,"score_spread":0.2752524950037464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}