{"id":"W2052686995","doi":"10.3892/ijo.2011.1272","title":"2-Triazenoazaindoles: A novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells","year":2011,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Kræftens Bekæmpelse","keywords":"Biology; Pancreatic cancer; Cancer research; Epidermal growth factor receptor; Cancer; Receptor tyrosine kinase; Oncogene; Tyrosine kinase; Cancer cell; Proteasome; Cell cycle; Growth factor receptor; Kinase; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006417409,0.000106659,0.000390809,0.0003310568,0.00002610162,0.000004093703,0.0002193221,0.0002364447,0.0008913337],"category_scores_gemma":[0.00008162077,0.00009681112,0.0001124343,0.0001089709,0.0002117581,0.0001534982,0.00003032241,0.000424189,8.017344e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967086,"about_ca_system_score_gemma":0.0001962218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002695852,"about_ca_topic_score_gemma":0.000121243,"domain_scores_codex":[0.9985531,0.0001403068,0.0008666043,0.0001161348,0.0001946684,0.0001292023],"domain_scores_gemma":[0.9983774,0.0003607127,0.0007276688,0.00004982956,0.0004092501,0.00007516342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001698684,0.0009259926,0.01186155,0.00002697118,0.0003224427,0.00001203611,0.001794192,0.0003155892,0.9690613,0.002767352,0.00009239451,0.01112145],"study_design_scores_gemma":[0.01136235,0.0008989717,0.1318845,0.0002478459,0.0002863794,0.0002002937,0.0007413483,0.0007142695,0.8320876,0.002987375,0.01839495,0.0001940722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959536,0.0003926634,0.0002807346,0.0004081871,0.0009433333,0.0001182488,0.00004412952,0.00000312862,0.001856038],"genre_scores_gemma":[0.9981996,0.0004760937,0.0008941734,0.0001482905,0.0001959702,0.000007504427,0.000004429133,0.000008331253,0.0000655805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1369737,"threshold_uncertainty_score":0.9759479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1885774169065351,"score_gpt":0.4573359228433265,"score_spread":0.2687585059367915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}