{"id":"W2052709196","doi":"10.1016/j.jmb.2006.01.029","title":"A 16 bp Rep Binding Element is Sufficient for Mediating Rep-dependent Integration into AAVS1","year":2006,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China","keywords":"Genome; Biology; Adeno-associated virus; Genetics; Transgene; Virus; Chromosome; Molecular biology; Gene; Virology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009572014,0.0007307972,0.0007567807,0.0007446099,0.0004547752,0.0007436572,0.0007952084,0.001256219,0.006150575],"category_scores_gemma":[0.00123235,0.001001904,0.0008155626,0.0002386243,0.0008341116,0.0007539026,0.0008625342,0.002140088,0.003452705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006519365,"about_ca_system_score_gemma":0.000880884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000946874,"about_ca_topic_score_gemma":0.001385642,"domain_scores_codex":[0.9990884,0.0001859303,0.0001272763,0.0001366985,0.0002532999,0.0002083681],"domain_scores_gemma":[0.9973301,0.001053856,0.0004326077,0.0003787411,0.0002135581,0.000591114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008354722,0.00004576412,0.00008862583,0.0000367322,0.000005109679,0.0000625467,0.00001556156,0.0000277276,0.9990915,0.0001085792,0.00003121101,0.0004031777],"study_design_scores_gemma":[0.00003075836,0.000197687,0.003631755,0.00001815946,0.00001893838,0.0004760226,0.00003896644,0.0006888908,0.9925154,0.0001536628,0.002215059,0.00001469209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835414,0.0009998099,0.01093746,0.0002789762,0.0001448594,0.0001105009,0.001004647,0.0004580424,0.002524247],"genre_scores_gemma":[0.9737015,0.0003713765,0.01578541,0.0001886718,0.00006604988,0.0001188307,0.003790144,0.0003553024,0.005622604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006150575,"threshold_uncertainty_score":0.0205757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281131167018671,"score_gpt":0.3298189830356439,"score_spread":0.3170076713654572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}