{"id":"W2052717087","doi":"10.1074/jbc.m701973200","title":"High Resolution Footprinting of the Hepatitis C Virus Polymerase NS5B in Complex with RNA","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Footprinting; NS5B; RNA; Polymerase; Nucleic acid; RNA-dependent RNA polymerase; RNA polymerase; Biochemistry; Biology; Binding site; Nucleoprotein; Nucleic acid structure; Molecular biology; DNA footprinting; Chemistry; Enzyme; DNA; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001925113,0.0002878461,0.0002610584,0.0002025446,0.0002647649,0.0003330469,0.0002388052,0.0002767219,0.001270237],"category_scores_gemma":[0.0002404046,0.0001759458,0.000254515,0.000156713,0.0002205323,0.000128739,0.0001920417,0.0005603523,0.0005153659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003085463,"about_ca_system_score_gemma":0.0001348199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112688,"about_ca_topic_score_gemma":0.0017223,"domain_scores_codex":[0.9998192,0.00003814165,0.000004787036,0.00004090637,0.00007032922,0.00002669887],"domain_scores_gemma":[0.9998423,0.00006032359,0.00002014653,0.00001999291,0.00002018068,0.00003714444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000537503,0.00001026657,0.0001434174,0.00002065355,0.000006126444,0.00002398035,0.0000311109,0.00005632629,0.9989366,0.00003863268,0.00001810872,0.0006611407],"study_design_scores_gemma":[0.00001141027,0.0001469548,0.004936549,0.000009738806,0.0000149682,0.0002949025,0.00007623216,0.002551807,0.9894931,0.0001024845,0.002352155,0.000009571521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885707,0.001354499,0.008129929,0.0001010906,0.0000220715,0.0000123441,0.0001934304,0.00006322978,0.001552656],"genre_scores_gemma":[0.9805889,0.0006378102,0.01500722,0.00006013387,0.00001000577,0.00001669837,0.0008163861,0.00004602492,0.002816872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270237,"threshold_uncertainty_score":0.004249334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498725436235069,"score_gpt":0.3146791989943495,"score_spread":0.2648066553708426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}