{"id":"W2052729921","doi":"10.1371/journal.ppat.1004684","title":"Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Instituto de Salud Carlos III; Fundação para a Ciência e a Tecnologia; Programa Operacional Temático Factores de Competitividade; International Business Machines Corporation; Ottawa Hospital Research Institute; Ministério da Ciência, Tecnologia e Ensino Superior; Ministerio de Economía y Competitividad; Agence Nationale de la Recherche","keywords":"AMPK; Cell biology; Leishmania infantum; Biology; Mitochondrion; Glycolysis; Intracellular parasite; Macrophage; Intracellular; Metabolism; In vitro; Phosphorylation; Immunology; Biochemistry; Protein kinase A; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005404306,0.0004358587,0.0007694277,0.0001648307,0.0003681236,0.0001468776,0.000469441,0.0001789505,0.0001566497],"category_scores_gemma":[0.002344075,0.0002907206,0.0002577546,0.0005416393,0.0003453718,0.000218722,0.0004272106,0.000676797,0.0004761859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170649,"about_ca_system_score_gemma":0.0002028543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001745257,"about_ca_topic_score_gemma":0.00003999654,"domain_scores_codex":[0.9961428,0.0002924212,0.0005180252,0.000668438,0.0014222,0.0009560997],"domain_scores_gemma":[0.9974169,0.0002740477,0.0001633694,0.001010205,0.0006022942,0.0005331885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004572463,0.0005925865,0.01200654,0.0001183331,0.0009394901,0.0004898381,0.004600595,0.00001000695,0.8905437,0.0002737556,0.08789016,0.002077729],"study_design_scores_gemma":[0.01871297,0.002301937,0.1544111,0.0006161308,0.002763077,0.0005690262,0.007948451,0.006085002,0.4048403,0.001642953,0.3973514,0.002757726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811994,0.006463766,0.00008040221,0.004550675,0.0007708623,0.001377524,0.00023073,0.0002502179,0.005076374],"genre_scores_gemma":[0.9928614,0.0005383941,0.001054316,0.0007750029,0.00162035,0.0002065966,0.00007025466,0.0001251128,0.002748565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4857034,"threshold_uncertainty_score":0.9999545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03889120123159928,"score_gpt":0.2813321296933711,"score_spread":0.2424409284617718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}