{"id":"W2052729921","doi":"10.1371/journal.ppat.1004684","title":"Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Instituto de Salud Carlos III; Fundação para a Ciência e a Tecnologia; Programa Operacional Temático Factores de Competitividade; International Business Machines Corporation; Ottawa Hospital Research Institute; Ministério da Ciência, Tecnologia e Ensino Superior; Ministerio de Economía y Competitividad; Agence Nationale de la Recherche","keywords":"AMPK; Cell biology; Leishmania infantum; Biology; Mitochondrion; Glycolysis; Intracellular parasite; Macrophage; Intracellular; Metabolism; In vitro; Phosphorylation; Immunology; Biochemistry; Protein kinase A; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015373,0.0002371301,0.00022954,0.0001780469,0.0001207938,0.0002512824,0.0001365608,0.0002159336,0.001011826],"category_scores_gemma":[0.00009443676,0.00009172252,0.0001953529,0.0001024211,0.0001669577,0.0001797494,0.0002247324,0.0003585412,0.0002165127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145719,"about_ca_system_score_gemma":0.0001562235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002190689,"about_ca_topic_score_gemma":0.0004603175,"domain_scores_codex":[0.9998958,0.00003243886,0.000007157864,0.00001236855,0.00001565846,0.00003659778],"domain_scores_gemma":[0.999958,0.000004724874,0.00001318516,0.000004969702,0.000008148814,0.0000109507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006040196,0.00006135195,0.001093174,0.0001283617,0.0000130195,0.00007803467,0.00002630669,0.00006081103,0.9934068,0.0001435544,0.0001325848,0.004251936],"study_design_scores_gemma":[0.0001401127,0.002349267,0.04945052,0.00004805759,0.0001257954,0.000756822,0.0002283822,0.001854283,0.933809,0.0004186566,0.01079956,0.00001953541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990466,0.006025892,0.001107329,0.0003546727,0.00005199287,0.00001840038,0.0002296375,0.0000986324,0.001647562],"genre_scores_gemma":[0.9969782,0.001406046,0.0005661887,0.00008922418,0.00001461614,0.00001456172,0.0001699581,0.000006816058,0.0007544872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011826,"threshold_uncertainty_score":0.003384888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03889120123159928,"score_gpt":0.2813321296933711,"score_spread":0.2424409284617718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}