{"id":"W2052731113","doi":"10.1371/journal.pone.0061918","title":"The Mode of Action of Recombinant Mycobacterium tuberculosis Shikimate Kinase: Kinetics and Thermodynamics Analyses","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Shikimate pathway; Isothermal titration calorimetry; Chemistry; Kinetics; Aromatic amino acids; Stereochemistry; Thermodynamics; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000435135,0.0003019978,0.0002853881,0.0002386857,0.0001417529,0.000306037,0.0005317486,0.0002365392,0.001196863],"category_scores_gemma":[0.0006561477,0.0001699678,0.0002970531,0.0002315994,0.0002133352,0.0003783211,0.0001267506,0.0004342464,0.0005791708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005621033,"about_ca_system_score_gemma":0.0002077622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104419,"about_ca_topic_score_gemma":0.0006380003,"domain_scores_codex":[0.9997948,0.00002734095,0.00001255408,0.00006434164,0.00006709685,0.00003398627],"domain_scores_gemma":[0.9997995,0.00009066792,0.00002718901,0.00001790576,0.00004936351,0.00001534275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001828351,0.00006060553,0.001753331,0.0001264982,0.00001877024,0.0000444859,0.0000628344,0.002291666,0.9900401,0.0006589178,0.0001084895,0.004651466],"study_design_scores_gemma":[0.000009288812,0.0001278481,0.003924227,0.000005229907,0.00001296857,0.00008315198,0.0000245536,0.02373418,0.9707325,0.0002546968,0.001070534,0.00002086541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812692,0.002082718,0.01351649,0.0001232331,0.00002957751,0.00004163177,0.0008181966,0.0001806821,0.00193821],"genre_scores_gemma":[0.995602,0.0006271238,0.001971436,0.00001651271,0.000009650931,0.0000319793,0.0003649934,0.00003692566,0.001339372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196863,"threshold_uncertainty_score":0.004078329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220789976577433,"score_gpt":0.2610814423837593,"score_spread":0.238873542617985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}