{"id":"W2052731113","doi":"10.1371/journal.pone.0061918","title":"The Mode of Action of Recombinant Mycobacterium tuberculosis Shikimate Kinase: Kinetics and Thermodynamics Analyses","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Shikimate pathway; Isothermal titration calorimetry; Chemistry; Kinetics; Aromatic amino acids; Stereochemistry; Thermodynamics; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004070387,0.00009876932,0.0001573312,0.00002171907,0.00003965787,0.00001419739,0.0001059725,0.00009642174,0.000005793846],"category_scores_gemma":[0.00004591645,0.00006951472,0.00004522499,0.00005544633,0.0001025867,0.000004885479,0.00007809376,0.00005284157,5.994809e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006869977,"about_ca_system_score_gemma":0.00001270961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001025577,"about_ca_topic_score_gemma":0.00004993519,"domain_scores_codex":[0.9993924,0.00003552081,0.000198173,0.0001390368,0.0001106629,0.0001241302],"domain_scores_gemma":[0.99938,0.00001777851,0.0001341518,0.0002927085,0.0001426984,0.00003267413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003639992,0.0001263487,0.0009643538,0.00008616081,0.0001917201,9.4005e-8,0.00001902303,0.00002182759,0.9963266,0.00009413251,0.000011215,0.002122149],"study_design_scores_gemma":[0.0001733849,0.0002556199,0.00890616,0.00003408971,0.0001204605,0.000001471715,0.00003967961,0.00609857,0.9829993,0.001250645,0.00002416322,0.00009651636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998564,0.0004557213,0.0004063071,0.0001188883,0.00003550015,0.000188993,0.00001924562,0.000004451528,0.0002069126],"genre_scores_gemma":[0.99609,0.002143873,0.001552634,0.00001913177,0.00002896009,0.00001881339,0.00004696733,0.0000129211,0.00008670879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01332734,"threshold_uncertainty_score":0.2834728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220789976577433,"score_gpt":0.2610814423837593,"score_spread":0.238873542617985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}