{"id":"W2052743974","doi":"10.1002/ana.22156","title":"Glycogen hyperphosphorylation underlies lafora body formation","year":2010,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Lafora disease; Glycogen; Glycogen branching enzyme; Glycogen synthase; Progressive myoclonus epilepsy; Endocrinology; Biology; GSK3B; Internal medicine; Glycogen debranching enzyme; Hyperphosphorylation; Biochemistry; Phosphatase; GSK-3; Medicine; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864667,0.0005101662,0.0002482994,0.0003853824,0.0002207246,0.0002010358,0.0002372574,0.0005027988,0.002927212],"category_scores_gemma":[0.0003083395,0.000157269,0.0002438319,0.0001037465,0.0006440228,0.000301534,0.0003616666,0.0004974242,0.0004204447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288341,"about_ca_system_score_gemma":0.0001338071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002631962,"about_ca_topic_score_gemma":0.0003399408,"domain_scores_codex":[0.9999026,0.00001325557,0.00001080744,0.00003399908,0.00001363252,0.00002573169],"domain_scores_gemma":[0.9996945,0.00003321155,0.000169138,0.00001706492,0.00001684949,0.00006935599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001091298,0.0001133598,0.01932402,0.0001051239,0.00003839263,0.007972113,0.00007845432,0.0001395141,0.9670409,0.0005710946,0.0004080503,0.003117732],"study_design_scores_gemma":[0.000241976,0.001749068,0.3849636,0.00006633752,0.0001928011,0.06160496,0.0003007766,0.003816287,0.5401352,0.001405851,0.005474932,0.00004827985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949483,0.000879842,0.002109463,0.0001746603,0.00002384908,0.00003844935,0.0003119146,0.0001282837,0.001385296],"genre_scores_gemma":[0.9984879,0.0002233515,0.0005359884,0.00005351333,0.00001731895,0.00002448218,0.0001901759,0.00001060667,0.0004564405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002927212,"threshold_uncertainty_score":0.009792507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816399937132953,"score_gpt":0.3171160117238667,"score_spread":0.2789520123525371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}