{"id":"W2052764032","doi":"10.1016/j.cmet.2008.05.004","title":"SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons","year":2008,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":330,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute on Aging","keywords":"Acetylation; Phosphorylation; Oxidative stress; Sirtuin 1; SIRT6; Biology; Calorie restriction; Signal transduction; Sirtuin; Oxidative phosphorylation; Cell biology; Sensitization; Knockout mouse; Biochemistry; Endocrinology; Downregulation and upregulation; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811467,0.0007518418,0.001039953,0.0005257447,0.0004435008,0.0005203754,0.0008339467,0.0006459013,0.004670274],"category_scores_gemma":[0.0001938189,0.000389231,0.0007838681,0.0003825648,0.0005400945,0.0005241665,0.0003175939,0.001549793,0.0008695003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006487326,"about_ca_system_score_gemma":0.0007451611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00320852,"about_ca_topic_score_gemma":0.006164579,"domain_scores_codex":[0.9998247,0.00001735694,0.00001807239,0.00003450572,0.00003407271,0.0000712522],"domain_scores_gemma":[0.9998541,0.00001372358,0.00003653951,0.00002812943,0.0000182077,0.00004919156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003095639,0.0002962841,0.0004730395,0.0001963616,0.000158966,0.0001676326,0.00006199563,0.0002884584,0.9855894,0.0004037156,0.0008509832,0.008417451],"study_design_scores_gemma":[0.0001915792,0.001133609,0.006531322,0.00001487927,0.0002021924,0.0002784678,0.0001564542,0.0007290467,0.9861585,0.000289635,0.004291208,0.00002295185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901817,0.002938258,0.001366273,0.0005482965,0.0002553396,0.00002293708,0.0007686153,0.0005394623,0.003379078],"genre_scores_gemma":[0.9918412,0.001536769,0.001027265,0.0001910125,0.00003259214,0.00003041067,0.0009563628,0.00006962459,0.004314751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004670274,"threshold_uncertainty_score":0.01562357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977067130771189,"score_gpt":0.2340565350650367,"score_spread":0.2142858637573248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}