{"id":"W2052769286","doi":"10.1039/c0sc00284d","title":"Synthesis enables a structural revision of the Mycobacterium tuberculosis-produced diterpene, edaxadiene","year":2010,"lang":"en","type":"article","venue":"Chemical Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Princeton University","keywords":"Natural product; Diterpene; Ketone; Mycobacterium tuberculosis; Total synthesis; Stereochemistry; Intramolecular force; Bicyclic molecule; Chemistry; Combinatorial chemistry; Tuberculosis; Organic chemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375806,0.0001385445,0.0002474739,0.00005010326,0.0001474964,0.00003561112,0.0005321967,0.00008865753,0.000271161],"category_scores_gemma":[0.003466556,0.00006904631,0.0001134272,0.0007190838,0.0009868342,0.0001499387,0.0002594445,0.0002851389,0.000007880488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000391196,"about_ca_system_score_gemma":0.000111787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000336625,"about_ca_topic_score_gemma":0.000002200616,"domain_scores_codex":[0.9985442,0.00001463706,0.0002451577,0.000467042,0.0004104796,0.0003184446],"domain_scores_gemma":[0.9987618,0.00008053001,0.0001070848,0.0006744417,0.0002279382,0.000148176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003341701,0.00002240689,0.001027546,0.00006576713,0.000004412749,6.511345e-7,0.00003723563,3.899339e-8,0.9837143,0.0000733382,0.0002287435,0.01479218],"study_design_scores_gemma":[0.00008085322,0.00001507044,0.01180519,0.0001304788,0.00004057279,0.00005061807,0.000008603991,0.00002768785,0.9859008,0.00004515914,0.001794693,0.0001003388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951125,0.0000589459,3.184582e-7,0.003653152,0.0004940173,0.0002181771,0.000008859797,0.00002223125,0.0004318246],"genre_scores_gemma":[0.9983259,0.00001354381,0.001064502,0.0001975793,0.0003029587,5.918133e-7,0.000001239811,0.000007671619,0.00008605792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01469184,"threshold_uncertainty_score":0.4150041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007947312536632911,"score_gpt":0.2421134296665479,"score_spread":0.2341661171299149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}