{"id":"W2052847333","doi":"10.1111/j.1365-2567.2004.01942.x","title":"Mutant forms of tumour necrosis factor receptor I that occur in TNF‐receptor‐associated periodic syndrome retain signalling functions but show abnormal behaviour","year":2004,"lang":"en","type":"article","venue":"Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Mutant; Receptor; Biology; HEK 293 cells; Cell biology; Cytoplasm; TRADD; Tumor necrosis factor alpha; Molecular biology; Transfection; Death domain; Apoptosis; Cell culture; Biochemistry; Programmed cell death; Genetics; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002054542,0.0003080352,0.0004347377,0.0001837736,0.0001569518,0.00002631349,0.0003397574,0.0005233654,0.0002463919],"category_scores_gemma":[0.0001221294,0.0003050123,0.0002415175,0.0002283796,0.0002353867,0.00002609124,0.0001491861,0.0003532832,0.00005916544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123965,"about_ca_system_score_gemma":0.0002217676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003625563,"about_ca_topic_score_gemma":0.0002539195,"domain_scores_codex":[0.9981923,0.0001042551,0.0005172185,0.000417419,0.0001470667,0.0006217154],"domain_scores_gemma":[0.9992055,0.00001770759,0.0002666357,0.0003377699,0.0001223497,0.00005001388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002074031,0.0002406186,0.02418935,0.0000120192,0.0001836385,0.00001043983,0.0004112488,0.0001310885,0.9740958,0.000024936,0.00004007011,0.0004533755],"study_design_scores_gemma":[0.003046937,0.001396389,0.130127,0.00007924777,0.00004452681,0.00005864971,0.002329977,0.000007398718,0.8611708,0.00006300345,0.001143893,0.0005321681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972093,0.001429023,0.0001461947,0.0001648913,0.0003852337,0.0003090305,0.0001869626,0.00003111468,0.0001382676],"genre_scores_gemma":[0.9982353,0.0004071439,0.00006034504,0.00006397747,0.0000223952,0.00006340208,0.000716801,0.00004210808,0.000388539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.112925,"threshold_uncertainty_score":0.9999402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009898250438356843,"score_gpt":0.2155579461793593,"score_spread":0.2056596957410025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}