{"id":"W2052849706","doi":"10.1371/journal.pone.0015902","title":"RNAi Screen of DAF-16/FOXO Target Genes in C. elegans Links Pathogenesis and Dauer Formation","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Biology; RNA interference; Gene knockdown; Gene; Genetic screen; Innate immune system; Genetics; Transcription factor; Phenotype; Caenorhabditis elegans; Cell biology; Immune system; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059473,0.0004615597,0.0004145431,0.0005246414,0.0003442345,0.0001989254,0.0004196219,0.0004065334,0.001152714],"category_scores_gemma":[0.000106103,0.000299867,0.000431539,0.0002916424,0.0001976726,0.0001017805,0.0002371733,0.000392664,0.000336505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004618193,"about_ca_system_score_gemma":0.0002894146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783654,"about_ca_topic_score_gemma":0.004261202,"domain_scores_codex":[0.9998248,0.00001244967,0.00002372288,0.00004780788,0.00006126336,0.00003002304],"domain_scores_gemma":[0.9998387,0.00003521632,0.00004464268,0.00001329953,0.00002343373,0.00004451642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003366894,0.00001642833,0.0001449385,0.0000169132,0.000002757272,0.00004621525,0.000006316313,0.00002543533,0.9992899,0.00001369372,0.00002308957,0.0003805307],"study_design_scores_gemma":[0.00003077243,0.0003077462,0.01524662,0.0000100123,0.00005088906,0.0002457426,0.00003018075,0.001365057,0.9804094,0.00001720188,0.002272808,0.00001379392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920224,0.0004444364,0.003228934,0.00006882529,0.00002022763,0.0001950144,0.002240564,0.0001805774,0.001599069],"genre_scores_gemma":[0.9659904,0.0009181261,0.01687298,0.0001951272,0.00001094102,0.0003315231,0.005756264,0.0001489197,0.009775685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783654,"threshold_uncertainty_score":0.003856242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547589427118322,"score_gpt":0.2052684783260629,"score_spread":0.1897925840548797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}