{"id":"W2052889619","doi":"10.1038/nature13392","title":"Ubiquitin is phosphorylated by PINK1 to activate parkin","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1484,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Parkin; PINK1; Ubiquitin; Ubiquitin ligase; Cell biology; Mitochondrion; Biology; Phosphorylation; Mitophagy; Kinase; Biochemistry; Chemistry; Molecular biology; Autophagy; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535915,0.0004248324,0.0001952086,0.0003030318,0.0003845671,0.0005550253,0.0002398695,0.0003007282,0.004186297],"category_scores_gemma":[0.0002366991,0.0002380403,0.0003105892,0.0001862451,0.0001775806,0.0007358129,0.0005840877,0.0004620674,0.001303838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000664025,"about_ca_system_score_gemma":0.0001890069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003220197,"about_ca_topic_score_gemma":0.0006967069,"domain_scores_codex":[0.999835,0.00001518057,0.000009425829,0.00005062106,0.00003594455,0.00005373865],"domain_scores_gemma":[0.9998809,0.00001628597,0.00003304522,0.00001937396,0.00001610956,0.00003431012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009261033,0.000098998,0.001732972,0.0001081965,0.00002629947,0.0004765681,0.00007100119,0.0003768783,0.9856469,0.002556122,0.0007546287,0.007225223],"study_design_scores_gemma":[0.0000267136,0.000126012,0.007144329,0.000007518134,0.000009078257,0.0006120162,0.00006172372,0.001205154,0.9852896,0.0007791743,0.004727013,0.00001174493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845449,0.002120878,0.005404734,0.0004381619,0.0001262271,0.00002971949,0.0004928647,0.0002029715,0.006639738],"genre_scores_gemma":[0.9922849,0.0004525249,0.001266826,0.00007611115,0.00001205009,0.000009774501,0.0004369531,0.00002566064,0.005435226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004186297,"threshold_uncertainty_score":0.01400459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003887209118197923,"score_gpt":0.2382040425889491,"score_spread":0.2343168334707512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}