{"id":"W2052893433","doi":"10.1053/joca.2002.0835","title":"15d-PGJ2 is acting as a ‘dual agent’ on the regulation of COX-2 expression in human osteoarthritic chondrocytes","year":2002,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Cyclooxygenase; Agonist; Activator (genetics); Peroxisome proliferator-activated receptor; Chemistry; Prostaglandin; Prostaglandin E; Metabolite; Prostaglandin D2; Pharmacology; Receptor; Prostaglandin f; Internal medicine; Endocrinology; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511585,0.0001893829,0.0001942098,0.00006643766,0.0001765629,0.00004254285,0.000102841,0.000177221,0.0003422049],"category_scores_gemma":[0.00009869467,0.0001596325,0.00007289178,0.000120006,0.0001271929,0.00001658521,0.00008578773,0.0001522934,0.00001410761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001405364,"about_ca_system_score_gemma":0.00001373333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005818246,"about_ca_topic_score_gemma":0.00004517243,"domain_scores_codex":[0.9987441,0.0001298873,0.0002948105,0.0003623771,0.0002042515,0.0002645774],"domain_scores_gemma":[0.9994078,0.0000364854,0.0001212079,0.0003150278,0.00004563291,0.00007388458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004411113,0.00004935615,0.0008861104,0.00001589718,0.000002610706,0.000004630583,0.000516435,0.000003507146,0.9920777,0.00004600039,0.0005999266,0.005753731],"study_design_scores_gemma":[0.001035554,0.0007259115,0.0002306053,0.0002064722,0.000005701832,0.00002026236,0.0004366256,0.000005829887,0.9917502,0.00005372303,0.005358273,0.0001708499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937564,0.002280454,0.000001582734,0.0001731924,0.0000822215,0.0002694574,0.00002406575,0.00001180751,0.003400894],"genre_scores_gemma":[0.9986014,0.0003789582,0.00002046394,0.0002729251,0.0001105108,0.0000483294,0.00002978479,0.0000264334,0.0005112346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005582881,"threshold_uncertainty_score":0.6509625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251071967882072,"score_gpt":0.2333946769335791,"score_spread":0.2208839572547584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}