{"id":"W2052898863","doi":"10.1002/jbmr.355","title":"The V–ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice","year":2011,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McGill University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research; University of Toronto","keywords":"Osteopetrosis; Protein subunit; Mutation; V-ATPase; ATPase; Biology; Genetics; Medicine; Internal medicine; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005297026,0.00175859,0.0006704614,0.00184437,0.0007404216,0.0006108368,0.000973113,0.001945412,0.005981486],"category_scores_gemma":[0.0002817769,0.0007991681,0.0009098008,0.0006563031,0.001018257,0.0002822845,0.0005597112,0.001343278,0.002285914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007280087,"about_ca_system_score_gemma":0.0005463551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001785753,"about_ca_topic_score_gemma":0.003391954,"domain_scores_codex":[0.9989009,0.0001876597,0.0001691861,0.0002233237,0.0003562959,0.0001625613],"domain_scores_gemma":[0.9993238,0.00009843214,0.0002744127,0.00005469599,0.00005299104,0.0001956663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002325227,0.00009352127,0.0002122572,0.00004962498,0.00002556576,0.0009230973,0.00003276874,0.00009177234,0.9963924,0.0002964259,0.0003320155,0.001317998],"study_design_scores_gemma":[0.0008185927,0.001682325,0.01362789,0.0001218812,0.0002437666,0.0184729,0.0001663402,0.003800773,0.9384269,0.0006026858,0.02193773,0.00009830416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972527,0.001596001,0.009688697,0.0008494118,0.0002628405,0.0003517566,0.007641892,0.001823392,0.005259138],"genre_scores_gemma":[0.9623865,0.001685632,0.01223597,0.000472688,0.0001240065,0.0003243402,0.004928019,0.000645989,0.01719684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005981486,"threshold_uncertainty_score":0.02001005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04382914783493107,"score_gpt":0.3251800597331336,"score_spread":0.2813509118982025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}