{"id":"W2052904519","doi":"10.1039/c0an00741b","title":"Towards an early diagnosis of HIV infection: an electrochemical approach for detection ofHIV-1 reverse transcriptase enzyme","year":2010,"lang":"en","type":"article","venue":"The Analyst","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada","keywords":"Detection limit; Chemistry; Self-assembled monolayer; Cystamine; Peptide; Reverse transcriptase; Dielectric spectroscopy; Electrochemistry; Biosensor; Enzyme; Combinatorial chemistry; Cyclic voltammetry; Ferrocene; Redox; Linear range; Monolayer; Electrode; Chromatography; Biochemistry; Inorganic chemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994236,0.0001443028,0.0001825947,0.0000594666,0.0001184392,0.00001941849,0.0001773744,0.0001838096,0.000002680489],"category_scores_gemma":[0.00004754771,0.00010503,0.0002168368,0.0001931476,0.0001341184,0.00001213281,0.00001869135,0.0001537492,2.605406e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008025768,"about_ca_system_score_gemma":0.00002043529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001407795,"about_ca_topic_score_gemma":0.0002301637,"domain_scores_codex":[0.9991219,0.00006711841,0.000209733,0.0003183895,0.0001066966,0.0001761386],"domain_scores_gemma":[0.9991457,0.000007771579,0.0001093326,0.0005125887,0.000153604,0.00007096364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001329962,0.0001510825,0.0008482215,0.000009442527,0.00008189285,1.647566e-7,0.0000268941,0.000006906842,0.9955496,0.00003168147,0.0001067854,0.003054344],"study_design_scores_gemma":[0.0001961368,0.0005042249,0.0005730143,0.000002014172,0.0001889529,0.000008679726,0.00003172506,0.001130538,0.9944401,0.0001020177,0.002676936,0.0001456929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8882992,0.00003160618,0.1112678,0.00006475161,0.00002691454,0.0001614159,0.00002891111,0.0000328935,0.0000865503],"genre_scores_gemma":[0.9905296,0.00005389093,0.008606129,0.00008864708,0.000287706,0.00005005104,0.0003014387,0.00001702684,0.00006553985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1026617,"threshold_uncertainty_score":0.4282998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110054093975457,"score_gpt":0.2674807415241918,"score_spread":0.2564753321266461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}