{"id":"W2052914628","doi":"10.1182/blood-2006-04-013813","title":"Expression of interleukin-3 receptor subunits on defined subpopulations of acute myeloid leukemia blasts predicts the cytotoxicity of diphtheria toxin interleukin-3 fusion protein against malignant progenitors that engraft in immunodeficient mice","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"","keywords":"Myeloid leukemia; Biology; Molecular biology; Progenitor cell; CD38; Diphtheria toxin; Leukemia; Haematopoiesis; Cancer research; Interleukin 15; CD34; Interleukin; Immunology; Stem cell; Cytokine; Cell biology; Microbiology; Toxin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007752715,0.0003459085,0.0006808784,0.0004618407,0.00007817239,0.00001627114,0.0004481215,0.000233172,0.0001731109],"category_scores_gemma":[0.0001435079,0.0002423708,0.0002627375,0.0007586437,0.0003307807,0.00008950187,0.0002337751,0.0004699637,0.000005313432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891737,"about_ca_system_score_gemma":0.0003166965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005757251,"about_ca_topic_score_gemma":0.0001408508,"domain_scores_codex":[0.9966862,0.0003822111,0.001041369,0.0004510777,0.0009797419,0.0004594145],"domain_scores_gemma":[0.9979966,0.0001910814,0.0005809368,0.0008274828,0.0003158279,0.0000881275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002395,0.001970336,0.01592578,0.0002399188,0.0001219164,0.00001706523,0.001291752,0.00009613228,0.9768234,0.00004922075,0.00005106178,0.001018431],"study_design_scores_gemma":[0.004657941,0.001259234,0.02872824,0.002230808,0.0001071292,0.00002331737,0.0003481183,0.0001317785,0.9622272,0.00003130027,0.00007616388,0.0001788116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959932,0.0002332386,0.00003811094,0.00009030766,0.0001068947,0.002768571,0.0001376479,0.00004098727,0.0005910516],"genre_scores_gemma":[0.9984803,0.00008270445,0.000408426,0.00001804476,0.00007160251,0.0002026523,0.0001380894,0.00006424695,0.0005339113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01459623,"threshold_uncertainty_score":0.9883595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01733544003318255,"score_gpt":0.2559289907733985,"score_spread":0.238593550740216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}