{"id":"W2052924269","doi":"10.1021/bi801931e","title":"Use of the Fused NS4A Peptide−NS3 Protease Domain To Study the Importance of the Helicase Domain for Protease Inhibitor Binding to Hepatitis C Virus NS3-NS4A","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease; NS2-3 protease; Helicase; Protease inhibitor (pharmacology); Biochemistry; Peptide; Chemistry; Peptide sequence; Biology; Enzyme; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00105899,0.0003378687,0.0004794485,0.00008154759,0.0003086711,0.00005347841,0.0007372971,0.0001559242,0.0000639548],"category_scores_gemma":[0.003095252,0.0001925545,0.000303211,0.0009433856,0.0002084925,0.00006738936,0.0003380141,0.000411388,0.00001149919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518507,"about_ca_system_score_gemma":0.0005280307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005366932,"about_ca_topic_score_gemma":0.0002373376,"domain_scores_codex":[0.9966741,0.0002295106,0.0007896172,0.000600524,0.001125512,0.000580787],"domain_scores_gemma":[0.9967524,0.0001982995,0.0003287382,0.001957993,0.0003719367,0.0003906213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007518053,0.0009132992,0.1067899,0.0001988434,0.00008433396,0.0000518062,0.001034825,0.000002765141,0.8840201,0.00001400688,0.004795205,0.001343027],"study_design_scores_gemma":[0.001886711,0.0007441426,0.0400379,0.0004435058,0.00007457274,0.00001690309,0.0004763498,0.00001944634,0.9535939,0.00007935808,0.002388012,0.0002392108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829875,0.00005479913,0.00006269872,0.004920542,0.00006941787,0.0111658,0.0005866675,0.000035261,0.0001173462],"genre_scores_gemma":[0.9944103,0.000007750044,0.002011519,0.00107896,0.0002673564,0.001400383,0.00001282288,0.00005009092,0.0007607685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06957374,"threshold_uncertainty_score":0.7852145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04323720809295767,"score_gpt":0.3278576748914286,"score_spread":0.2846204667984709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}