{"id":"W2052924269","doi":"10.1021/bi801931e","title":"Use of the Fused NS4A Peptide−NS3 Protease Domain To Study the Importance of the Helicase Domain for Protease Inhibitor Binding to Hepatitis C Virus NS3-NS4A","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease; NS2-3 protease; Helicase; Protease inhibitor (pharmacology); Biochemistry; Peptide; Chemistry; Peptide sequence; Biology; Enzyme; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377642,0.0003177592,0.0002727068,0.000144116,0.0001900284,0.0002394027,0.0002997546,0.0004278212,0.000448846],"category_scores_gemma":[0.000172352,0.0001257445,0.0003629937,0.0002068545,0.0001979644,0.0002265153,0.0001909522,0.0005210159,0.0002081892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004010184,"about_ca_system_score_gemma":0.0001982927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136279,"about_ca_topic_score_gemma":0.0006864324,"domain_scores_codex":[0.9998367,0.00003431671,0.00001378276,0.00003268596,0.00004643468,0.00003596155],"domain_scores_gemma":[0.9998684,0.00004338342,0.00003280291,0.0000157098,0.00001272524,0.00002701342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004370486,0.00002689429,0.0001107529,0.00001236466,0.000004634558,0.00002671354,0.000009443081,0.0000843052,0.9994512,0.00002797623,0.000004643065,0.0001972569],"study_design_scores_gemma":[0.000007866038,0.0001938224,0.001224172,0.000001410491,0.000008599991,0.0001375328,0.00001381141,0.001345696,0.9965731,0.00001237129,0.0004783504,0.00000337315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971149,0.0003073322,0.00219217,0.00003294438,0.00000799709,0.00002325554,0.0001147498,0.00001143587,0.0001951402],"genre_scores_gemma":[0.9931178,0.0003178419,0.005330213,0.00002786772,0.00000402735,0.00001776227,0.0004274007,0.00001215148,0.0007448723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136279,"threshold_uncertainty_score":0.002909601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04323720809295767,"score_gpt":0.3278576748914286,"score_spread":0.2846204667984709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}