{"id":"W2052937262","doi":"10.1016/j.abb.2014.01.017","title":"A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity","year":2014,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Lipoxygenase; Enzyme; Mutation; Domain (mathematical analysis); Chemistry; Biochemistry; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002890741,0.001001663,0.0006529279,0.000511913,0.0004345137,0.0006848312,0.001020392,0.00129417,0.005308399],"category_scores_gemma":[0.0003568594,0.0004036812,0.0007868602,0.0004312437,0.001014459,0.0003103781,0.0004998377,0.001687989,0.002020359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005274742,"about_ca_system_score_gemma":0.0004525973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001536977,"about_ca_topic_score_gemma":0.001094896,"domain_scores_codex":[0.9994189,0.0001100949,0.0001171445,0.0001237549,0.0001297903,0.000100474],"domain_scores_gemma":[0.999235,0.000276061,0.0001697947,0.0001074926,0.00003526609,0.0001763691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002170707,0.0001022033,0.00007237853,0.00002566716,0.000019412,0.0002430457,0.00001367026,0.0000925168,0.9984992,0.0002691108,0.00004703145,0.0003987339],"study_design_scores_gemma":[0.00005230945,0.0001354243,0.0007676107,0.000006344513,0.00003167809,0.0005688159,0.00001907316,0.001215745,0.9958859,0.00006704372,0.001238568,0.00001145716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863492,0.0006718937,0.008855871,0.000357005,0.000305802,0.00008926367,0.0009120793,0.0004303842,0.002028431],"genre_scores_gemma":[0.9935894,0.0001963358,0.002681357,0.0000890038,0.00002652138,0.00004936415,0.0006134416,0.0001278553,0.002626714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005308399,"threshold_uncertainty_score":0.01775831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004385729650182892,"score_gpt":0.2183876043110885,"score_spread":0.2140018746609056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}