{"id":"W2052937459","doi":"10.1126/science.1234150","title":"Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors","year":2013,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":811,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Immunogen; Germline; Epitope; Virology; Biology; Antibody; Cell biology; Genetics; Monoclonal antibody; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039675,0.0003390328,0.0002442996,0.0002417709,0.0001346689,0.0003032228,0.00031748,0.0002999516,0.0008958025],"category_scores_gemma":[0.000165276,0.0002127403,0.0001880381,0.0001570788,0.0001993425,0.0002218686,0.0002599843,0.0004493131,0.0003333681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178874,"about_ca_system_score_gemma":0.0002699019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000217108,"about_ca_topic_score_gemma":0.000500767,"domain_scores_codex":[0.9999163,0.00001689581,0.000004997039,0.00001482107,0.00002156008,0.00002538798],"domain_scores_gemma":[0.9999559,0.000009687868,0.00001159153,0.000005286129,0.00000810626,0.000009409472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314038,0.000217131,0.0003779327,0.000152794,0.00001456917,0.0001954389,0.00004054721,0.01472011,0.9652789,0.004728698,0.0003767847,0.01376563],"study_design_scores_gemma":[0.0001777321,0.001275121,0.000472964,0.00002133065,0.00002472851,0.0002964298,0.00003745031,0.03171863,0.9536545,0.001114335,0.01118986,0.00001687376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9346468,0.001681882,0.05545618,0.0002757878,0.00006684219,0.0003330598,0.0002107955,0.0002044965,0.007124162],"genre_scores_gemma":[0.9320179,0.001736046,0.0632665,0.0002258631,0.00001171882,0.0001963795,0.0002148578,0.00005109969,0.002279536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008958025,"threshold_uncertainty_score":0.002996743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031159889670068,"score_gpt":0.2508711034385146,"score_spread":0.2305595045418139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}