{"id":"W2052953726","doi":"10.1158/1538-7445.am2013-lb-63","title":"Abstract LB-63: Relationship between tumor biomarkers (BM) and efficacy in EMILIA, a phase III study of trastuzumab emtansine (T-DM1) in HER2-positive metastatic breast cancer (MBC).","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Trastuzumab emtansine; Lapatinib; Medicine; Trastuzumab; Hazard ratio; Metastatic breast cancer; Internal medicine; Oncology; Breast cancer; Cancer; Antibody-drug conjugate; Progression-free survival; Capecitabine; Proportional hazards model; Chemotherapy; Antibody; Confidence interval; Monoclonal antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002909643,0.0003562946,0.001010272,0.001586232,0.0001626688,0.00007916025,0.0003863671,0.0001314331,0.001397919],"category_scores_gemma":[0.0008033966,0.0003231049,0.0000839686,0.002844251,0.0006942938,0.0003158811,0.0001988788,0.001755147,0.00003674755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002106594,"about_ca_system_score_gemma":0.002157594,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1105731,"about_ca_topic_score_gemma":0.01398658,"domain_scores_codex":[0.9940968,0.0008318365,0.001095085,0.0009381321,0.001821645,0.001216564],"domain_scores_gemma":[0.9957941,0.002031468,0.0001618767,0.0006631973,0.0007744093,0.0005749349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003389835,0.005188311,0.9196471,0.001195539,0.000467965,0.0006513401,0.009345341,0.00005145293,0.01531587,0.00001295964,0.001809661,0.04292466],"study_design_scores_gemma":[0.02046168,0.001427873,0.9676723,0.001720383,0.00007711963,0.00002201799,0.006296132,0.000112614,0.001825245,0.00007687646,0.00004375218,0.0002639293],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891412,0.00198582,0.00000376908,0.002514142,0.00005822277,0.005540346,0.0003036806,0.0000270216,0.0004258483],"genre_scores_gemma":[0.9971889,0.0003047395,0.00005230396,0.00004288452,0.0001493305,0.001879155,0.00003422187,0.00008833765,0.0002600853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09658654,"threshold_uncertainty_score":0.9999221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1545835589769086,"score_gpt":0.4888655201552625,"score_spread":0.3342819611783538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}