{"id":"W2052959623","doi":"10.1371/journal.pone.0083644","title":"The Role of Intestinal Microbiota in Development of Irinotecan Toxicity and in Toxicity Reduction through Dietary Fibres in Rats","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Toxicity; Gut flora; Bifidobacterium; Butyrate; Resistant starch; Biology; Prebiotic; Microbiology; Inulin; Colorectal cancer; Feces; Pharmacology; Bacteria; Lactobacillus; Food science; Biochemistry; Internal medicine; Cancer; Medicine; Starch","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002350172,0.0006097531,0.0004966389,0.0007272606,0.0002624962,0.0003027961,0.0002331985,0.0005685152,0.001073856],"category_scores_gemma":[0.0002426843,0.0003907759,0.0004764686,0.0002441029,0.0005352767,0.0005077696,0.000324757,0.001255907,0.0002450267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004598323,"about_ca_system_score_gemma":0.0005418822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001486343,"about_ca_topic_score_gemma":0.002021919,"domain_scores_codex":[0.9997419,0.00004096676,0.00001587255,0.00007241673,0.00004327365,0.00008569473],"domain_scores_gemma":[0.9996124,0.00002625266,0.00009935713,0.00004472214,0.00003436236,0.0001829412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007906205,0.0009721417,0.002884584,0.00004987582,0.00002547743,0.0001434358,0.000091987,0.0001122358,0.9842403,0.00008162151,0.00006420565,0.003427988],"study_design_scores_gemma":[0.000280866,0.02241727,0.08100787,0.00003029094,0.0001401072,0.0003857969,0.000465081,0.002107384,0.8904924,0.0002861074,0.002324836,0.00006191079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982176,0.0003812358,0.0006754866,0.0001039313,0.00002470022,0.00002849563,0.0002039292,0.00002882157,0.0003357156],"genre_scores_gemma":[0.9939528,0.0006254061,0.001509486,0.000134634,0.00001264055,0.0001223664,0.0003551621,0.00001990411,0.003267519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486343,"threshold_uncertainty_score":0.003592432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176644637514667,"score_gpt":0.2377535395150463,"score_spread":0.2159870931398996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}