{"id":"W2052966638","doi":"10.1074/jbc.m113.456996","title":"The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Histone H3; Histone; Histone deacetylase 5; Cell biology; Kinase; Mef2; Nuclear export signal; HDAC4; Transcription factor; Acetylation; Phosphorylation; Biology; Chemistry; Histone deacetylase; Biochemistry; Gene; Enhancer; Cell nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006234082,0.0004278119,0.0001671601,0.0001634588,0.0001768104,0.0002069952,0.0000953327,0.0001291427,0.00227415],"category_scores_gemma":[0.00006713993,0.0001525344,0.0002544129,0.0001178369,0.00014278,0.0001508606,0.0002762967,0.0003313759,0.0008681485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000363604,"about_ca_system_score_gemma":0.000225197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395109,"about_ca_topic_score_gemma":0.001199796,"domain_scores_codex":[0.9999501,0.00000698185,0.000002981176,0.00001085559,0.00001320631,0.0000159237],"domain_scores_gemma":[0.9999679,0.000004230729,0.00001004488,0.000003041171,0.000004358251,0.00001041515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001240585,0.00001162838,0.0006130628,0.00004931355,0.000008810357,0.00006921717,0.00001073278,0.0001106236,0.996971,0.0001607616,0.0001356601,0.001735088],"study_design_scores_gemma":[0.00005263975,0.0002575425,0.01470191,0.000009857851,0.00001742366,0.0005798748,0.00004119104,0.001819499,0.9734875,0.0002477811,0.008775815,0.000008929802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804577,0.005911154,0.006071009,0.0003240597,0.0001193142,0.00003213783,0.0006334195,0.0002411423,0.006210073],"genre_scores_gemma":[0.9914915,0.001593888,0.00177879,0.00006781389,0.00002237024,0.00002582617,0.0008221535,0.00002426871,0.004173369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00227415,"threshold_uncertainty_score":0.007607818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370382445118051,"score_gpt":0.2725446681324206,"score_spread":0.2588408436812401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}