{"id":"W2052987680","doi":"10.1128/aac.00263-09","title":"Profound Antiviral Effect of Oral Administration of MIV-210 on Chronic Hepadnaviral Infection in a Woodchuck Model of Hepatitis B","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Woodchuck hepatitis virus; Medicine; Viremia; Oral administration; Hepatitis B virus; Pharmacology; Bioavailability; Hepatitis B; Placebo; Internal medicine; Gastroenterology; Immunology; Virus; Virology; Hepadnaviridae; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566482,0.0004923341,0.0004591116,0.000229515,0.0002081229,0.000227004,0.0002391201,0.0003250609,0.001331061],"category_scores_gemma":[0.0001097955,0.0001669626,0.0002138248,0.0001042395,0.0002647225,0.0002444476,0.0001140889,0.0008722848,0.0003141362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296339,"about_ca_system_score_gemma":0.0003749148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466005,"about_ca_topic_score_gemma":0.002227337,"domain_scores_codex":[0.9999106,0.00001986625,0.000006090297,0.000012522,0.00001354543,0.00003731898],"domain_scores_gemma":[0.9999236,0.00001141816,0.00001270644,0.000009135738,0.000008477467,0.00003465044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002265026,0.001368467,0.0001695908,0.00007889915,0.00001312426,0.00007850976,0.00004604676,0.0001957186,0.9888098,0.0001162397,0.0001745793,0.006684227],"study_design_scores_gemma":[0.0004512553,0.03726613,0.00497261,0.0000180286,0.00005575339,0.0002504271,0.00005229052,0.001443616,0.9531758,0.00008566926,0.002208945,0.00001945757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969517,0.0007595127,0.0005453202,0.00007801668,0.00005395082,0.00005700288,0.0002076177,0.00008648549,0.001260394],"genre_scores_gemma":[0.9942608,0.0007779823,0.001035265,0.00005819887,0.00002280033,0.00007542469,0.0004508623,0.00001422518,0.00330453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466005,"threshold_uncertainty_score":0.004452825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643109601281548,"score_gpt":0.2997734216572671,"score_spread":0.2833423256444516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}