{"id":"W2052991207","doi":"10.1056/nejmoa012354","title":"Lopinavir–Ritonavir versus Nelfinavir for the Initial Treatment of HIV Infection","year":2002,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":650,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; University of Toronto; University Health Network","funders":"","keywords":"Lopinavir; Lopinavir/ritonavir; Ritonavir; Nelfinavir; Medicine; Virology; Protease inhibitor (pharmacology); Human immunodeficiency virus (HIV); Pharmacology; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102544,0.0001837421,0.0005298631,0.0001697614,0.00008028023,0.000005270331,0.00006534622,0.00006309317,0.000366518],"category_scores_gemma":[0.0003053399,0.00009131808,0.0001704185,0.0001709921,0.0001043906,0.00006755537,0.00000745333,0.0001253106,0.00001044972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001676034,"about_ca_system_score_gemma":0.0001444715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005689509,"about_ca_topic_score_gemma":0.00002594923,"domain_scores_codex":[0.9986967,0.00004270961,0.0005576193,0.0001113306,0.0003909007,0.0002007361],"domain_scores_gemma":[0.9984675,0.0006082374,0.0003128919,0.000163756,0.0002004996,0.0002470902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007567605,0.0009514604,0.01701804,0.00007403263,0.001438198,0.0002795268,0.005946808,0.00003501836,0.0005159377,0.0002426547,0.05753129,0.9083995],"study_design_scores_gemma":[0.1997792,0.01230287,0.00762713,0.0004513562,0.001845086,0.000919254,0.0002576646,0.0002512751,0.002065436,0.0001427933,0.7742292,0.0001287245],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8009954,0.01465664,0.004024142,0.1664637,0.005099353,0.001665572,0.0000182413,0.00004612749,0.00703079],"genre_scores_gemma":[0.9793385,0.005618116,0.0009617336,0.0001615229,0.006236184,0.00001369737,0.00002072914,0.00002487982,0.007624684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9082707,"threshold_uncertainty_score":0.4013115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08347689925760145,"score_gpt":0.3403015943720378,"score_spread":0.2568246951144364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}