{"id":"W2052999387","doi":"10.1016/j.humimm.2014.10.004","title":"Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling","year":2014,"lang":"en","type":"article","venue":"Human Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Streptococcus pneumoniae; PI3K/AKT/mTOR pathway; Protein kinase B; Immunology; Monocyte; Phagocytosis; Macrophage; Disease; Signal transduction; Biology; Medicine; Microbiology; Cell biology; Internal medicine; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003740432,0.0003363906,0.0007121575,0.0001561013,0.0003016411,0.000017755,0.0005749174,0.0005371636,0.0007043798],"category_scores_gemma":[0.0001106325,0.0002827855,0.0001063263,0.0001747591,0.001089207,0.0001040014,0.0003213595,0.0008398833,0.0001356333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006765846,"about_ca_system_score_gemma":0.00003897526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006256867,"about_ca_topic_score_gemma":0.00009700397,"domain_scores_codex":[0.9973354,0.0007347997,0.0007549102,0.0005323103,0.00004658856,0.0005960285],"domain_scores_gemma":[0.9983299,0.0005861096,0.0003608873,0.0006440372,0.0000640166,0.00001507244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001822018,0.0001170552,0.006861527,0.00001512994,0.0002923533,0.00002453668,0.001957856,0.00005181389,0.9823276,0.0003602513,0.00005950507,0.007750152],"study_design_scores_gemma":[0.008107631,0.001326666,0.3752464,0.0002483341,0.0001135344,0.0001314794,0.001367807,0.000008776922,0.6051207,0.004023717,0.003726258,0.000578716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975533,0.02236066,0.00003409743,0.0001211285,0.0008936708,0.0003667297,0.00001750897,0.000071656,0.0006015298],"genre_scores_gemma":[0.998733,0.0004006178,0.00009516683,0.00008942467,0.00001932931,0.00004324534,0.00009848683,0.00004605634,0.0004747174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3772069,"threshold_uncertainty_score":0.9999624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009643300977267314,"score_gpt":0.2384353897888987,"score_spread":0.2287920888116314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}