{"id":"W2053001938","doi":"10.1371/journal.pone.0042791","title":"Simultaneous Detection of Ca2+ and Diacylglycerol Signaling in Living Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Diacylglycerol kinase; Second messenger system; Intracellular; Inositol; Phospholipase C; Cell biology; Phospholipase; Phosphoinositide phospholipase C; Fluorescence; Calcium; Biology; Biophysics; Biochemistry; Chemistry; Signal transduction; Protein kinase C; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001782261,0.00007254112,0.0001174543,0.00003369281,0.00002456153,0.000006453857,0.00003948206,0.0000857254,0.00002590448],"category_scores_gemma":[0.0001016784,0.00007445832,0.00002245323,0.00004222567,0.00001456114,0.000004073017,0.00003907051,0.00005557606,0.00000192177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007022038,"about_ca_system_score_gemma":0.000006557193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002388677,"about_ca_topic_score_gemma":0.00001008377,"domain_scores_codex":[0.9994562,0.00003728205,0.0001367829,0.0001202755,0.00008620637,0.0001632263],"domain_scores_gemma":[0.9997309,0.00004884507,0.0000523974,0.00008856492,0.00002982288,0.00004948636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001874879,0.0001943286,0.002526202,0.000043622,0.00003207224,4.068784e-7,0.0001743054,0.0001018781,0.9959712,0.000002434567,3.584006e-7,0.000934466],"study_design_scores_gemma":[0.0001126477,0.000122114,0.0001584037,0.0000691757,0.00002353684,9.335733e-7,0.00007855032,0.0006894877,0.9986355,0.00000690892,0.00001754027,0.00008517812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977835,0.00106604,0.0009537047,0.000002724518,0.00003566145,0.00009579705,0.000002301331,0.000004821359,0.00005540204],"genre_scores_gemma":[0.9984691,0.0001271456,0.001177163,0.00001896189,0.0001363861,0.000006486132,0.000002536065,0.00001310541,0.00004907846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002664346,"threshold_uncertainty_score":0.3036322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426395175350436,"score_gpt":0.2021198113353297,"score_spread":0.1878558595818254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}