{"id":"W2053020515","doi":"10.1002/mc.20419","title":"Development of aberrant crypt foci in the colons of <i>ob</i>/<i>ob</i> and <i>db</i>/<i>db</i> mice: Evidence that leptin is not a promoter","year":2008,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Terry Fox Foundation","keywords":"Azoxymethane; Leptin; Aberrant crypt foci; Internal medicine; Endocrinology; Biology; Crypt; Carcinogen; Carcinogenesis; Ratón; Leptin receptor; Colorectal cancer; Obesity; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002113067,0.0006611181,0.0004783563,0.001383282,0.0003048108,0.0004646469,0.0002292718,0.0006856958,0.001834229],"category_scores_gemma":[0.0001657073,0.0005527918,0.0005671308,0.000403967,0.0005291661,0.0004214953,0.0003336472,0.001511316,0.0004465562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349403,"about_ca_system_score_gemma":0.0002258623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001546981,"about_ca_topic_score_gemma":0.002323783,"domain_scores_codex":[0.9996253,0.00003620406,0.00004532807,0.0001222916,0.00008524843,0.0000856519],"domain_scores_gemma":[0.9991566,0.00006207306,0.0003264655,0.0000575173,0.000050565,0.0003466707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005246598,0.00004925301,0.0006928504,0.00002142114,0.000008896613,0.00005393761,0.00002352121,0.00001118307,0.9982792,0.00002461274,0.00001092532,0.0002994627],"study_design_scores_gemma":[0.0001010722,0.002770259,0.1111246,0.00002635576,0.0001061462,0.002040781,0.000381401,0.000623605,0.8810368,0.0001124964,0.001647029,0.00002957535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963594,0.0009542403,0.001048465,0.00009582075,0.00002326828,0.00003000997,0.0007441779,0.00005744195,0.0006871067],"genre_scores_gemma":[0.9896626,0.001089304,0.003816626,0.0001505246,0.00002181587,0.00009321122,0.001379852,0.00009840589,0.003687584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001834229,"threshold_uncertainty_score":0.00613606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08227641122808639,"score_gpt":0.2690888445928458,"score_spread":0.1868124333647594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}