{"id":"W2053041004","doi":"10.1021/bm0703923","title":"Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles","year":2007,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; International Business Machines Corporation; Eli Lilly and Company","keywords":"Insulin; Bioavailability; Chitosan; Chemistry; Polysaccharide; Nanoparticle; Hypoglycemia; Gastrointestinal tract; Oral administration; Pharmacology; Internal medicine; Endocrinology; Medicine; Biochemistry; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751405,0.0003465297,0.0002600057,0.0001639036,0.0000928942,0.0002335318,0.0001459001,0.0002743856,0.0006937185],"category_scores_gemma":[0.0002148576,0.0001537804,0.0001703845,0.0000988199,0.0001403991,0.000169088,0.0001216957,0.0004819983,0.000151169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002928952,"about_ca_system_score_gemma":0.0002553911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007544211,"about_ca_topic_score_gemma":0.0005429418,"domain_scores_codex":[0.9999163,0.00001125628,0.000005959926,0.00002286456,0.00002554762,0.0000181009],"domain_scores_gemma":[0.9998926,0.00002330372,0.00003254364,0.00000995724,0.00002016131,0.0000214437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002624096,0.0000404587,0.0001349375,0.00003753337,0.000006288387,0.00003222632,0.0000116309,0.0001126813,0.9952456,0.00004508138,0.00003219788,0.004038807],"study_design_scores_gemma":[0.00002807938,0.001098968,0.001427873,0.000006709239,0.00003161159,0.00007279404,0.000007248172,0.0008499013,0.9955359,0.00001834208,0.000918513,0.000004175933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941796,0.001409035,0.00311451,0.00007051159,0.00003674018,0.00002309631,0.00009063146,0.00006135555,0.001014434],"genre_scores_gemma":[0.9935673,0.0008223468,0.002938729,0.00004050523,0.00001915272,0.00002448981,0.0001804283,0.00002631918,0.002380677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007544211,"threshold_uncertainty_score":0.002320707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0836717508672078,"score_gpt":0.4221877677164008,"score_spread":0.338516016849193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}