{"id":"W2053041004","doi":"10.1021/bm0703923","title":"Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles","year":2007,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; International Business Machines Corporation; Eli Lilly and Company","keywords":"Insulin; Bioavailability; Chitosan; Chemistry; Polysaccharide; Nanoparticle; Hypoglycemia; Gastrointestinal tract; Oral administration; Pharmacology; Internal medicine; Endocrinology; Medicine; Biochemistry; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00167656,0.000214501,0.0003733267,0.0002221966,0.00006464383,0.00000725237,0.0002765741,0.0002630754,0.0002167812],"category_scores_gemma":[0.000261781,0.0002098779,0.00009280756,0.0005366986,0.0003921603,0.0001077205,0.0000962569,0.0002484442,0.00009698491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001130545,"about_ca_system_score_gemma":0.00006677936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000343323,"about_ca_topic_score_gemma":0.0007227611,"domain_scores_codex":[0.997788,0.000339698,0.0008027364,0.0003525059,0.0001723445,0.0005446776],"domain_scores_gemma":[0.9987905,0.0004296093,0.0002176184,0.0002694851,0.0001123318,0.000180478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007268978,0.0004000389,0.06582407,0.0000436291,0.00004712714,0.0001549192,0.0004328872,0.00002922174,0.9131417,0.001166204,0.00008533544,0.01794801],"study_design_scores_gemma":[0.00200039,0.000134658,0.05084173,0.00002069199,0.00002629075,0.00002431197,0.0003881173,0.0002515324,0.9392309,0.0004232926,0.006419274,0.0002388024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963185,0.001430071,0.0004099607,0.0001617527,0.0004611585,0.0004137312,0.00006236369,0.0000827033,0.0006597572],"genre_scores_gemma":[0.9986563,0.00003802158,0.0008672272,0.0002693995,0.00004811535,0.00001419596,0.000006926172,0.0000211832,0.0000786791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02608925,"threshold_uncertainty_score":0.8558571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0836717508672078,"score_gpt":0.4221877677164008,"score_spread":0.338516016849193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}