{"id":"W2053115489","doi":"10.1111/j.1538-7836.2006.01730.x","title":"The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay","year":2006,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Thrombin generation; Clotting factor; Coagulation; Factor IX; Waveform; Medicine; Clotting time; Recombinant DNA; Thrombin; Tissue factor; Immunology; Internal medicine; Chemistry; Platelet; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009818551,0.0002400877,0.0009822773,0.0003833812,0.0001527934,0.00005702731,0.00009831203,0.0001451641,0.00009035545],"category_scores_gemma":[0.0001499201,0.0001302158,0.0001991561,0.0004999107,0.0002614062,0.0001775552,0.00005764007,0.0002320425,3.923695e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541649,"about_ca_system_score_gemma":0.0001468948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002156979,"about_ca_topic_score_gemma":0.0005637375,"domain_scores_codex":[0.9974664,0.0001189266,0.0009605895,0.0002345412,0.0009378981,0.0002816251],"domain_scores_gemma":[0.9984793,0.0002023823,0.0004962774,0.0002067835,0.0004431524,0.0001721116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001472084,0.001471561,0.3350373,0.0005853822,0.004481199,0.00003911648,0.001498954,0.00001588012,0.5876636,0.00008351092,0.002477648,0.06517383],"study_design_scores_gemma":[0.004501024,0.00112431,0.6272872,0.0002576184,0.0009930281,0.00004905024,0.0003657264,0.001105937,0.3638056,0.0001155758,0.0002100237,0.0001849234],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953443,0.001657204,0.0000422939,0.002349773,0.00005294592,0.0003350886,0.00015276,0.000003423557,0.00006215894],"genre_scores_gemma":[0.9951023,0.004259659,0.0004014763,0.00002530887,0.0000708764,0.000003889962,0.000008337003,0.0000170615,0.0001110564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2922499,"threshold_uncertainty_score":0.5310047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09617448010747456,"score_gpt":0.3342577476042057,"score_spread":0.2380832674967311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}