{"id":"W2053126030","doi":"10.1158/1538-7445.am2013-864","title":"Abstract 864: ANG4043: A new brain-penetrant peptide-antibody conjugate that reduces tumor growth in a HER2-positive orthotopic tumor model.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Angiochem (Canada)","funders":"","keywords":"Transcytosis; LRP1; Monoclonal antibody; Conjugate; Peptide; Receptor; Blood–brain barrier; Cancer research; Antibody; In vitro; Receptor tyrosine kinase; Tumor microenvironment; Biology; Cell biology; Chemistry; Pharmacology; Biochemistry; Immunology; Endocrinology; Central nervous system; LDL receptor; Lipoprotein; Endocytosis; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208561,0.0004213979,0.0001967403,0.0002317065,0.00009262274,0.0001579534,0.0002221658,0.0003702184,0.001231199],"category_scores_gemma":[0.00005267698,0.0001217343,0.0001748735,0.0001465622,0.000124298,0.0001675008,0.00008522037,0.0004374024,0.0003790664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858211,"about_ca_system_score_gemma":0.0002075072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005891332,"about_ca_topic_score_gemma":0.0006118978,"domain_scores_codex":[0.9999228,0.000013616,0.000004727154,0.00001369051,0.00002487998,0.00002021682],"domain_scores_gemma":[0.9999624,0.000004869986,0.00001185961,0.000002967292,0.000004800098,0.00001308499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000147458,0.00009574906,0.00005747149,0.00002832951,0.000006707097,0.00006107176,0.000005076635,0.0001074845,0.9975509,0.00006884612,0.0001318069,0.001739194],"study_design_scores_gemma":[0.00009456703,0.001807035,0.001986475,0.000002964997,0.00002094917,0.0004311555,0.000004317853,0.0008377132,0.9920717,0.00003328933,0.002705178,0.000004643295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926273,0.001019438,0.003025715,0.0001474304,0.00007320926,0.00008754576,0.0004241636,0.0001512033,0.002443917],"genre_scores_gemma":[0.9885159,0.0008601829,0.004041821,0.0001003346,0.00002536443,0.00006723031,0.0008760049,0.0000325134,0.005480753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231199,"threshold_uncertainty_score":0.004118741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04524306884702095,"score_gpt":0.3740412239470097,"score_spread":0.3287981550999888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}