{"id":"W2053132003","doi":"10.1523/jneurosci.3849-05.2006","title":"Mislocalized Rhodopsin Does Not Require Activation to Cause Retinal Degeneration and Neurite Outgrowth in<i>Xenopus laevis</i>","year":2006,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research; Karl Kirchgessner Foundation; National Institutes of Health; Foundation Fighting Blindness","keywords":"Rhodopsin; Xenopus; Cell biology; Retinal degeneration; Retinitis pigmentosa; Neurite; Biology; Transducin; Retinal; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215275,0.0005730641,0.000356897,0.0002848336,0.0002305087,0.0005234662,0.000399152,0.0005370995,0.001429925],"category_scores_gemma":[0.0001495942,0.0003687471,0.0005166149,0.0001273305,0.0003244504,0.0003100079,0.0002983379,0.001071666,0.0006379037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006164984,"about_ca_system_score_gemma":0.0003043799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00263543,"about_ca_topic_score_gemma":0.003313404,"domain_scores_codex":[0.9995874,0.00005893505,0.00007863318,0.00009296301,0.0001021335,0.00008000183],"domain_scores_gemma":[0.9996566,0.00006296227,0.0001111619,0.00004626538,0.00002644237,0.00009659395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003423108,0.00001752414,0.00006255379,0.00001612599,0.000004661697,0.00003705928,0.00001116112,0.00002521684,0.9996127,0.0000386748,0.000009144115,0.0001310506],"study_design_scores_gemma":[0.00001857932,0.0002584367,0.002273901,0.000007719424,0.00001629928,0.0002817863,0.0000257496,0.0006621053,0.9953908,0.00001984246,0.001039384,0.000005410418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952509,0.0006990157,0.001742484,0.0001016849,0.0000406535,0.00004250937,0.0004116342,0.0001151072,0.001596033],"genre_scores_gemma":[0.9884702,0.0005771702,0.003081501,0.00009628888,0.00001382558,0.00007088017,0.001067459,0.0001254082,0.00649725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00263543,"threshold_uncertainty_score":0.005240142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297548681705124,"score_gpt":0.2571365975773284,"score_spread":0.2441611107602771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}