{"id":"W2053132705","doi":"10.1128/jvi.05505-11","title":"Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus Pathogenicity","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency","keywords":"Biology; Myxoma virus; Vaccinia; Virus; Virology; Protein kinase R; Viral replication; Poxviridae; Interferon; Innate immune system; Antibody-dependent enhancement; Viral transformation; Immune system; Protein kinase A; Cell biology; Immunology; Kinase; Genetics; Gene; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153905,0.0003146104,0.0002529064,0.0003126051,0.0001348682,0.0002344781,0.0001360258,0.0002555438,0.0004298571],"category_scores_gemma":[0.0002216213,0.0001072959,0.0003326334,0.0002225334,0.0002150179,0.000305653,0.0001760641,0.0003694877,0.0001566408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245426,"about_ca_system_score_gemma":0.0001158884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002511659,"about_ca_topic_score_gemma":0.000177873,"domain_scores_codex":[0.9998939,0.00002550236,0.00001241496,0.00002164879,0.00001975995,0.0000267267],"domain_scores_gemma":[0.9998376,0.00005310719,0.00003541057,0.00001723499,0.00001278199,0.00004387434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001448848,0.00002121563,0.00039895,0.00001574388,0.000004193372,0.00005788126,0.00001395853,0.00003254915,0.998912,0.00005056531,0.00000403552,0.0003440418],"study_design_scores_gemma":[0.0000430187,0.000954784,0.04798144,0.000007582861,0.00004945509,0.00181634,0.0001209863,0.001631291,0.9445025,0.0001293646,0.002750726,0.00001258136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988005,0.0003982314,0.0004318455,0.00001013502,0.000004498098,0.000008625051,0.0001058761,0.000004722511,0.0002355245],"genre_scores_gemma":[0.9970689,0.0003980185,0.001025179,0.00003124297,0.000006822805,0.00001877067,0.0008917463,0.0000114316,0.0005478296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004298571,"threshold_uncertainty_score":0.001629174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0445756021385194,"score_gpt":0.2957531422073469,"score_spread":0.2511775400688275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}