{"id":"W2053134875","doi":"10.1155/2013/402369","title":"Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy","year":2013,"lang":"en","type":"review","venue":"BioMed Research International","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Medical Research Council; Women and Children's Health Research Institute; Children's Health Research Institute; Muscular Dystrophy Canada; Parent Project Muscular Dystrophy","keywords":"Exon skipping; Duchenne muscular dystrophy; Dystrophin; Medicine; Bioinformatics; Clinical trial; Muscular dystrophy; Disease; Oligonucleotide; Genetic counseling; Computational biology; Exon; Biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323275,0.0006417129,0.0008749157,0.00128056,0.0001692133,0.0004479675,0.0005247814,0.0007677319,0.00210999],"category_scores_gemma":[0.0002627716,0.0002299457,0.000357186,0.0007926102,0.0002304153,0.0006928249,0.000346761,0.001292752,0.001225933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003450084,"about_ca_system_score_gemma":0.0003734318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005627522,"about_ca_topic_score_gemma":0.001453673,"domain_scores_codex":[0.9999048,0.00001366342,0.0000132963,0.00001646175,0.00004081482,0.00001097649],"domain_scores_gemma":[0.9999307,0.00002804389,0.000012332,0.000001959683,0.00001884675,0.000008136803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009195953,0.0001229227,0.0001014782,0.009734306,0.00007076852,0.0004123141,0.00006486693,0.0004821552,0.01042626,0.003017237,0.01573595,0.9597399],"study_design_scores_gemma":[0.00004454288,0.0002948405,0.0008102873,0.001580451,0.0001005858,0.002193631,0.00004394344,0.0001921178,0.004406632,0.001076928,0.9892333,0.00002273368],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006763861,0.9968951,0.0004174729,0.0001793596,0.0002316612,0.00001035294,0.0000203161,0.00001577925,0.001553591],"genre_scores_gemma":[0.002457603,0.9952893,0.0004543253,0.000198997,0.00008190492,0.0000134848,0.0000378429,0.000002743219,0.0014638],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00210999,"threshold_uncertainty_score":0.00705868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1864776138142793,"score_gpt":0.461187867000787,"score_spread":0.2747102531865077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}