{"id":"W2053134875","doi":"10.1155/2013/402369","title":"Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy","year":2013,"lang":"en","type":"review","venue":"BioMed Research International","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Medical Research Council; Women and Children's Health Research Institute; Children's Health Research Institute; Muscular Dystrophy Canada; Parent Project Muscular Dystrophy","keywords":"Exon skipping; Duchenne muscular dystrophy; Dystrophin; Medicine; Bioinformatics; Clinical trial; Muscular dystrophy; Disease; Oligonucleotide; Genetic counseling; Computational biology; Exon; Biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006741701,0.0002540023,0.0004958811,0.0003763692,0.0001285355,0.00002884269,0.0006315552,0.000347345,0.00008278842],"category_scores_gemma":[0.0002766374,0.0002063226,0.0003698201,0.0001544175,0.0002090506,0.000005546843,0.0002504909,0.0002028444,0.00003398168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005491761,"about_ca_system_score_gemma":0.0004820283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001705408,"about_ca_topic_score_gemma":0.000003891611,"domain_scores_codex":[0.9980087,0.0001887371,0.0005285821,0.0005198049,0.0003552529,0.0003988994],"domain_scores_gemma":[0.9987056,0.00008829503,0.0002144217,0.0003428266,0.000550813,0.00009807165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001357909,0.0002312905,0.000002016928,0.001712229,0.0009293071,0.000001626846,0.00003556278,0.000001077345,0.07638156,0.0001337992,0.003965,0.9164708],"study_design_scores_gemma":[0.0006247043,0.0001409429,0.00002637449,0.0005786628,0.00001315378,0.000003271956,0.00002643465,0.00001532955,0.004858061,0.00003639099,0.9934707,0.0002060165],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01465201,0.9815807,0.000682487,0.0000517848,0.0008888358,0.001719497,0.0001515844,0.00001134656,0.0002617566],"genre_scores_gemma":[0.001109628,0.9877073,0.007300017,0.00001597507,0.0005513962,0.0006864586,0.002119973,0.00005045296,0.0004588532],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9895056,"threshold_uncertainty_score":0.841359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1864776138142793,"score_gpt":0.461187867000787,"score_spread":0.2747102531865077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}