{"id":"W2053188578","doi":"10.1038/cmi.2014.72","title":"Transgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44+CD62Lhigh IL-7R+ CTLs with up- and downregulation of anti- and pro-apoptosis genes","year":2014,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Biology; CTL*; Immunology; Priming (agriculture); Immune system; CD8; Transgene; Virology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004030287,0.0004112877,0.0008114679,0.0002964685,0.0002291361,0.00002308162,0.0001645129,0.0003886835,0.00002820795],"category_scores_gemma":[0.00002112151,0.0003456987,0.00008832163,0.0001546298,0.0007115571,0.0001150346,0.0001032402,0.000288262,0.000001057303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001280101,"about_ca_system_score_gemma":0.00003844699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343859,"about_ca_topic_score_gemma":0.000003263567,"domain_scores_codex":[0.9979016,0.0006430622,0.0005590891,0.0004435339,0.00005917463,0.0003935416],"domain_scores_gemma":[0.9988741,0.0002111512,0.0002708198,0.0004759494,0.0001338007,0.0000341783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001917058,0.0001366719,0.003352786,0.0001841926,0.0009658999,0.000002521027,0.0006655445,0.00001082567,0.9594449,0.0002709118,6.220063e-7,0.03304803],"study_design_scores_gemma":[0.004667019,0.001144486,0.1631677,0.0001245615,0.0002712101,0.0001590665,0.0001097862,0.00004096861,0.829731,0.00006861628,0.0001977714,0.0003178233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8553436,0.1323245,0.01164418,0.00006414347,0.00008895113,0.0004845668,0.00001183173,0.00003157509,0.00000662817],"genre_scores_gemma":[0.9905223,0.009021671,0.0001833583,0.00003096717,0.00000672723,0.00001977576,0.0001223084,0.00004582933,0.00004710425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1598149,"threshold_uncertainty_score":0.9998995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007867809078512462,"score_gpt":0.2011129319243209,"score_spread":0.1932451228458085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}