{"id":"W2053188578","doi":"10.1038/cmi.2014.72","title":"Transgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44+CD62Lhigh IL-7R+ CTLs with up- and downregulation of anti- and pro-apoptosis genes","year":2014,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Biology; CTL*; Immunology; Priming (agriculture); Immune system; CD8; Transgene; Virology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401908,0.0008438585,0.0004958426,0.0005094893,0.0001805778,0.0005325475,0.0002393893,0.0006587624,0.002061302],"category_scores_gemma":[0.0001464077,0.0003082916,0.0003276677,0.0001780292,0.0003296284,0.0003709244,0.0002713734,0.002634509,0.0008760869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005013439,"about_ca_system_score_gemma":0.0003649801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002605625,"about_ca_topic_score_gemma":0.0005401578,"domain_scores_codex":[0.9995302,0.00006044271,0.00003204585,0.00008007114,0.00008844424,0.0002088634],"domain_scores_gemma":[0.9997616,0.00004002183,0.0000725192,0.00002675274,0.0000202438,0.0000788268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012079,0.000198657,0.0001054275,0.00002399335,0.000006097244,0.00002978188,0.00001309312,0.0001184317,0.9981627,0.0001003829,0.00005647395,0.0009838244],"study_design_scores_gemma":[0.000113482,0.001212201,0.002715824,0.00001132374,0.00005255495,0.0002827328,0.00004074446,0.002021224,0.991775,0.0001571139,0.001607409,0.00001029702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943185,0.000663374,0.002793425,0.0001434692,0.000107924,0.00006211755,0.0002720627,0.0002369839,0.001402142],"genre_scores_gemma":[0.9946635,0.0002723547,0.001661411,0.00008940473,0.00005028863,0.00004494352,0.0004323139,0.00005412281,0.002731703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061302,"threshold_uncertainty_score":0.006895781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007867809078512462,"score_gpt":0.2011129319243209,"score_spread":0.1932451228458085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}