{"id":"W2053199152","doi":"10.3390/cancers3033506","title":"An Evidence-Based Approach to the Use of Predictive Biomarkers in the Treatment of Non- Small Cell Lung Cancer (NSCLC)","year":2011,"lang":"en","type":"article","venue":"Cancers","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Oncology; Lung cancer; Internal medicine; ERCC1; Epidermal growth factor receptor; Randomized controlled trial; Erlotinib; Clinical trial; Biomarker; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06734666,0.002383511,0.01060936,0.01679648,0.001048008,0.00719775,0.004898321,0.005982763,0.005045031],"category_scores_gemma":[0.1566609,0.001389852,0.009841591,0.009393083,0.001748787,0.006198048,0.003041709,0.005206231,0.001204405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009079128,"about_ca_system_score_gemma":0.01920495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005383676,"about_ca_topic_score_gemma":0.0103309,"domain_scores_codex":[0.9317523,0.03509578,0.0218721,0.002235395,0.008514087,0.0005303289],"domain_scores_gemma":[0.8397706,0.119143,0.01887281,0.002810853,0.01798361,0.001419154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005867369,0.00009654638,0.000948021,0.7281299,0.01467859,0.0001322487,0.0002350248,0.0005810875,0.0003744581,0.00499163,0.01236849,0.2368772],"study_design_scores_gemma":[0.0006906997,0.0002889726,0.001673178,0.9108222,0.02681398,0.0001193431,0.0001569556,0.0005068823,0.0002350664,0.006038917,0.05259845,0.0000554464],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003142551,0.9813753,0.002013808,0.01076639,0.001466716,0.001874202,0.0004393917,0.00004084906,0.001709075],"genre_scores_gemma":[0.02238563,0.9375901,0.02349137,0.009959926,0.001369801,0.004097285,0.0005701685,0.00002322393,0.0005126329],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.06734666,"threshold_uncertainty_score":0.3561674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08881224349185424,"score_gpt":0.3338571486428721,"score_spread":0.2450449051510178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}