{"id":"W2053212967","doi":"10.1016/j.ejphar.2010.02.035","title":"Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway","year":2010,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Hypericin; Glutamate receptor; Protein kinase A; Chemistry; Exocytosis; Glutaminase; Synaptosome; Pharmacology; Biology; Biochemistry; Kinase; Receptor; In vitro; Secretion","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002013722,0.0003083964,0.0004469688,0.0003682288,0.0003286652,0.00005869548,0.001866086,0.00005719993,0.0003123472],"category_scores_gemma":[0.000715936,0.0001785623,0.000183804,0.0008851658,0.00126429,0.0003256613,0.0003895549,0.002767796,0.00005491606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004405749,"about_ca_system_score_gemma":0.0002523782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004482582,"about_ca_topic_score_gemma":0.000003136229,"domain_scores_codex":[0.9907832,0.006191909,0.0009589599,0.0004897257,0.0008588942,0.0007173011],"domain_scores_gemma":[0.9973907,0.001112654,0.0007662304,0.0003053028,0.0002012256,0.0002238938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001660531,0.0007439285,0.0001023691,0.00001547002,0.00002222481,0.004385305,0.0006127036,0.00006715708,0.9892682,0.00005428241,0.0006320007,0.00243578],"study_design_scores_gemma":[0.002515777,0.001061521,0.001572507,0.00002044259,0.00004803479,0.001490149,0.0001225007,0.0002185645,0.9888266,0.00002880158,0.003933003,0.0001620991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926459,0.00003872104,0.00002614364,0.00418019,0.001853697,0.0009507824,0.00001747683,0.00002185774,0.000265273],"genre_scores_gemma":[0.9964718,0.00009567911,0.00001281868,0.002949163,0.0003105022,0.00002497013,3.210768e-7,0.00004689326,0.00008787782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006607484,"threshold_uncertainty_score":0.9995329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020471120399148,"score_gpt":0.3035586296260763,"score_spread":0.2733539184220848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}