{"id":"W2053219172","doi":"10.1038/gene.2015.7","title":"Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-Ak NOD mice","year":2015,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Cedars-Sinai Medical Center","keywords":"Nod; Biology; Major histocompatibility complex; NOD mice; Autoimmunity; Thyroid peroxidase; Immunology; Immune system; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004382434,0.0006711077,0.0003368913,0.0005837295,0.0002197586,0.0005363482,0.0005389469,0.0009109565,0.002145012],"category_scores_gemma":[0.0004281742,0.0003095696,0.0004762064,0.0001420163,0.0005188351,0.0004569074,0.000316227,0.001831542,0.0006511472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579796,"about_ca_system_score_gemma":0.0002047922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003568104,"about_ca_topic_score_gemma":0.0006022548,"domain_scores_codex":[0.9995537,0.00007049821,0.00006606575,0.0001176312,0.00008606506,0.0001060987],"domain_scores_gemma":[0.9991948,0.0001083797,0.0003025527,0.0001474114,0.00005039747,0.000196518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005463929,0.00008631151,0.0003915277,0.00005843605,0.00001823679,0.00009582794,0.00001421863,0.00005636647,0.9972231,0.0001409301,0.00009926287,0.001269402],"study_design_scores_gemma":[0.0002527974,0.00105471,0.009369121,0.00003232103,0.0001236308,0.001351627,0.00007910423,0.0009465103,0.9834622,0.0002853226,0.003028434,0.00001420191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885522,0.00218901,0.004109818,0.0006274027,0.0001533,0.00003174692,0.0006398951,0.0003614987,0.003335089],"genre_scores_gemma":[0.992142,0.0009162432,0.002231939,0.0003527354,0.00006023282,0.00005258332,0.0003708316,0.00008410294,0.003789326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002145012,"threshold_uncertainty_score":0.007175803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07080875332068515,"score_gpt":0.3100261936485453,"score_spread":0.2392174403278601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}