{"id":"W2053226232","doi":"10.15252/embr.201438840","title":"Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy","year":2014,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Manton Center for Orphan Disease Research, Boston Children's Hospital","keywords":"Epilepsy; Function (biology); Genetically modified organism; Cotransporter; Neuroscience; Biology; Genetics; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007019,0.0002051455,0.0003605412,0.0002650789,0.0001512831,0.00002870891,0.0002711203,0.00008859449,0.0002338129],"category_scores_gemma":[0.0002621897,0.0001882775,0.0001211688,0.0004864905,0.0003784649,0.000153165,0.00008880537,0.0003854156,0.00001491063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002632243,"about_ca_system_score_gemma":0.0001100201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000204536,"about_ca_topic_score_gemma":0.000008049999,"domain_scores_codex":[0.9963813,0.0005740246,0.0008545024,0.0008814341,0.0007575519,0.0005511318],"domain_scores_gemma":[0.9988964,0.00009907641,0.0002698668,0.0004938131,0.00005643823,0.0001844006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009957237,0.0002975727,0.02803589,0.00002644687,0.000001444384,0.0008944241,0.00005165504,0.0002192722,0.9695764,0.0003356838,0.0001084805,0.0003531253],"study_design_scores_gemma":[0.0007173328,0.0009270087,0.1001106,0.0000193414,0.00001384404,0.0002978545,0.000002229242,0.0008250048,0.8949724,0.001136938,0.0007987091,0.0001786775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972504,0.00001348729,0.0002119841,0.0002060096,0.0007697026,0.000424199,0.000002267805,0.00006063439,0.001061354],"genre_scores_gemma":[0.9979996,0.00003136534,0.00001857923,0.001450619,0.00009858179,0.00005289518,0.00000128067,0.00002776411,0.0003192977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07460401,"threshold_uncertainty_score":0.7677734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03181546463311396,"score_gpt":0.3114454112282686,"score_spread":0.2796299465951546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}