{"id":"W2053226232","doi":"10.15252/embr.201438840","title":"Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy","year":2014,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Manton Center for Orphan Disease Research, Boston Children's Hospital","keywords":"Epilepsy; Function (biology); Genetically modified organism; Cotransporter; Neuroscience; Biology; Genetics; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631195,0.0006503558,0.0003816223,0.0003309052,0.0002558312,0.0001997489,0.0002509835,0.0004248801,0.001811838],"category_scores_gemma":[0.000375512,0.000154719,0.0002860476,0.0002760621,0.000951478,0.0001900342,0.0004203365,0.000426789,0.0002769613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538033,"about_ca_system_score_gemma":0.0003263403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220208,"about_ca_topic_score_gemma":0.001582557,"domain_scores_codex":[0.9998676,0.00003936496,0.0000265984,0.00002384393,0.00002050207,0.0000220876],"domain_scores_gemma":[0.9998386,0.0000498757,0.00004705306,0.00002545537,0.00001052396,0.00002849827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001916381,0.0001759559,0.002825889,0.0001591583,0.00008444249,0.01307014,0.0001573898,0.000607859,0.9736205,0.001016783,0.0003132633,0.006052217],"study_design_scores_gemma":[0.00111953,0.002851389,0.1030616,0.00007099804,0.0008616343,0.08193304,0.0007845486,0.01019221,0.7884585,0.003164665,0.007351679,0.0001503026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998044,0.000224194,0.000878176,0.000110438,0.00002390713,0.00002030244,0.0002183482,0.00004177554,0.0004388751],"genre_scores_gemma":[0.9990292,0.0001434358,0.0003443591,0.00003406976,0.000006225392,0.000009872218,0.0001339482,0.00001702042,0.0002820225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811838,"threshold_uncertainty_score":0.006061196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03181546463311396,"score_gpt":0.3114454112282686,"score_spread":0.2796299465951546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}