{"id":"W2053240723","doi":"10.1074/jbc.m808831200","title":"Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Subfamily; Bacterial outer membrane; Neisseria meningitidis; Lipid bilayer; Recombinant DNA; Antibody; Biology; Neisseria; Linker; Antigen; Peptide sequence; Vesicle; Chemistry; Biochemistry; Membrane; Genetics; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005591515,0.0001905328,0.0001267891,0.0000873821,0.0001728148,0.0001838636,0.0001671659,0.0002478082,0.001111766],"category_scores_gemma":[0.0001346426,0.00006152239,0.0001593875,0.00005978556,0.0001381816,0.000124773,0.0001844388,0.0003820966,0.0003744405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504106,"about_ca_system_score_gemma":0.0001184085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002964977,"about_ca_topic_score_gemma":0.0001906804,"domain_scores_codex":[0.9999681,0.000006382396,0.000001599392,0.000004978006,0.00001084252,0.000008213075],"domain_scores_gemma":[0.9999442,0.000008344393,0.0000117189,0.000004853059,0.00001036555,0.00002050765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001640601,0.00003089179,0.0007238579,0.00002385921,0.000003422957,0.0001764372,0.00002004332,0.0005483678,0.9961253,0.0004151032,0.00004783924,0.001720857],"study_design_scores_gemma":[0.00009953735,0.001318133,0.02310695,0.00001771414,0.00003202091,0.00196045,0.0001516612,0.01140653,0.9553719,0.001415428,0.005104097,0.00001551889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973334,0.000168756,0.0009577243,0.00005278985,0.000006989475,0.000008341177,0.00006337707,0.00001655723,0.001392018],"genre_scores_gemma":[0.9984193,0.0000844812,0.0008242514,0.00003569846,0.000004433795,0.000005810254,0.0001475935,0.00000433727,0.0004741776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111766,"threshold_uncertainty_score":0.00371927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03228482298691214,"score_gpt":0.2366287222197379,"score_spread":0.2043438992328258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}