{"id":"W2053240723","doi":"10.1074/jbc.m808831200","title":"Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Subfamily; Bacterial outer membrane; Neisseria meningitidis; Lipid bilayer; Recombinant DNA; Antibody; Biology; Neisseria; Linker; Antigen; Peptide sequence; Vesicle; Chemistry; Biochemistry; Membrane; Genetics; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001766942,0.0001098812,0.0002600469,0.000009997646,0.0002908918,0.000005986359,0.0003291699,0.0001739901,0.0003265502],"category_scores_gemma":[0.0002611931,0.00004141499,0.0002745176,0.00007179879,0.0001756768,0.00003297171,0.00007729883,0.0002579486,0.000001408794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002182892,"about_ca_system_score_gemma":0.00006002883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002593899,"about_ca_topic_score_gemma":0.000001357491,"domain_scores_codex":[0.9992893,0.00005325559,0.0004020105,0.00008270715,0.00001700563,0.0001556587],"domain_scores_gemma":[0.9991902,0.0001155542,0.000356046,0.0001569445,0.0001685343,0.00001278214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004490347,0.00002701313,0.008325588,0.00001101777,0.0001899959,2.96553e-7,0.00005453153,0.00000391808,0.9900782,0.00000536568,0.000572014,0.0002830034],"study_design_scores_gemma":[0.0007609206,0.0001383073,0.04837671,0.00002759853,0.00005105628,0.0007755968,0.0000790298,0.000002243641,0.9446402,0.00002315449,0.005059796,0.00006545251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953519,0.003402044,0.000008149198,0.000536821,0.0005514222,0.0001042017,0.00001788729,0.000005897898,0.00002164294],"genre_scores_gemma":[0.9991732,0.0002681919,0.00002023566,0.00003013594,0.0001719064,0.000006763751,0.000002826057,0.000004390377,0.0003223783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04543809,"threshold_uncertainty_score":0.3575496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03228482298691214,"score_gpt":0.2366287222197379,"score_spread":0.2043438992328258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}