{"id":"W2053317847","doi":"10.1016/j.chembiol.2009.04.005","title":"Functional Rescue of DeltaF508-CFTR by Peptides Designed to Mimic Sorting Motifs","year":2009,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Rosalind Franklin University of Medicine and Science","keywords":"Mutant; Endoplasmic reticulum; Biology; Cell biology; Structural motif; Cystic fibrosis; Transduction (biophysics); Molecular biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003586879,0.0005645367,0.000494689,0.000175401,0.0002838953,0.0004071394,0.0004980329,0.0008815835,0.001916574],"category_scores_gemma":[0.0003230254,0.000306598,0.000493099,0.0001427462,0.0004738753,0.0003152033,0.0003286159,0.001251225,0.0007574975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004086291,"about_ca_system_score_gemma":0.0003177495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005235623,"about_ca_topic_score_gemma":0.000475555,"domain_scores_codex":[0.9998142,0.00003924101,0.00002686486,0.00002913398,0.00004048021,0.00005004477],"domain_scores_gemma":[0.9996815,0.0001063131,0.00007479716,0.00003327509,0.0000291845,0.00007486624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001960962,0.00003031822,0.00004701437,0.00004310756,0.000008411675,0.0001499231,0.00001859994,0.0002574678,0.9983793,0.0002223467,0.00004437562,0.0006029478],"study_design_scores_gemma":[0.00007908285,0.0001853768,0.0004130019,0.000007112829,0.00001273515,0.000365176,0.00002250832,0.001024154,0.9965104,0.00005512739,0.001316791,0.000008470086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918573,0.0007896241,0.005272089,0.0002140726,0.0001517413,0.00007901743,0.0004042777,0.00009144103,0.001140442],"genre_scores_gemma":[0.9920228,0.0004208329,0.004773655,0.0001089427,0.00001792969,0.0000429591,0.0005429573,0.00005371675,0.002016221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916574,"threshold_uncertainty_score":0.006411612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710250242787259,"score_gpt":0.3073658728309945,"score_spread":0.2902633704031219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}