{"id":"W2053366042","doi":"10.1016/j.biotechadv.2013.05.006","title":"Biotechnological advances on Penicillin G acylase: Pharmaceutical implications, unique expression mechanism and production strategies","year":2013,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Penicillin; Biochemical engineering; Escherichia coli; Antibiotics; Chemistry; Penicillin amidase; Biotechnology; Biochemistry; Biology; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001889478,0.0005622226,0.000813061,0.0002753875,0.0002221825,0.00005232983,0.0004936591,0.001976216,0.00001887289],"category_scores_gemma":[0.0003335252,0.0004169938,0.0001745979,0.0003669707,0.0005400424,0.0000463811,0.0003018854,0.0006217074,0.00002987686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004109519,"about_ca_system_score_gemma":0.0001027834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.249682e-7,"about_ca_topic_score_gemma":0.000004213229,"domain_scores_codex":[0.997526,0.0001439667,0.0005516722,0.001275388,0.0001308342,0.0003720966],"domain_scores_gemma":[0.9985175,0.00004649792,0.0004276976,0.0008485153,0.00008553551,0.00007432969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001569474,0.0001037505,7.77947e-7,0.00116665,0.00004937861,0.000001325261,0.00000204973,0.000006577775,0.08989472,0.01159028,0.0002639875,0.8969048],"study_design_scores_gemma":[0.00009236131,0.000278528,3.600292e-7,0.0006095539,0.00009547234,0.00005531027,0.00005564591,0.00000222619,0.2544428,0.002222432,0.7417922,0.0003531766],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007539028,0.9935058,0.003463364,0.0005632083,0.0002286437,0.001145085,0.00004528186,0.0002042307,0.00009048464],"genre_scores_gemma":[0.0009877684,0.9952671,0.002062136,0.0000464795,0.0001659919,0.0006774716,0.0005553074,0.00005118567,0.0001865723],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8965516,"threshold_uncertainty_score":0.9998282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03285436382349647,"score_gpt":0.3532037234854506,"score_spread":0.3203493596619542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}