{"id":"W2053377122","doi":"10.1038/ja.2010.136","title":"Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides","year":2010,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Lantibiotics; Nisin; Bacteriocin; Antimicrobial peptides; Antibacterial peptide; Biology; Computational biology; Peptide; Biochemistry; Bacteria; Microbiology; Antimicrobial; Antibacterial activity; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001115856,0.00008845547,0.0001408687,0.00002288255,0.0002318588,0.00002964102,0.0002638019,0.00007543956,0.00005130718],"category_scores_gemma":[0.0001072939,0.00002641097,0.00005143779,0.0002986242,0.0001491458,0.00008748578,0.00005853847,0.0005832766,0.000001291859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005370407,"about_ca_system_score_gemma":0.00003141576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002377272,"about_ca_topic_score_gemma":0.0006639298,"domain_scores_codex":[0.9990555,0.0001506301,0.0003192555,0.00006520574,0.0002627021,0.0001466896],"domain_scores_gemma":[0.9991189,0.0003670675,0.0003469783,0.00005568084,0.00007891667,0.0000324067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000133683,0.0001545466,0.2078424,0.000009059729,0.00006211732,0.000002160302,0.0003361885,0.00006594922,0.7849334,0.003337017,0.00006840934,0.003055068],"study_design_scores_gemma":[0.000201621,0.0001649588,0.9610591,0.00005030731,0.00003816541,0.00006935222,0.001522579,0.0000702895,0.03133104,0.00490611,0.0004989028,0.00008759394],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976938,0.00004258762,0.00005561587,0.001487183,0.0003748386,0.00009191449,0.000017659,0.000003104002,0.0002333485],"genre_scores_gemma":[0.9996168,0.0001299806,0.0001121469,0.00004870289,0.00007307595,2.136631e-9,0.000003409068,9.801121e-7,0.00001489244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7536024,"threshold_uncertainty_score":0.2534079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0694625558615527,"score_gpt":0.2465280780220764,"score_spread":0.1770655221605237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}