{"id":"W2053377820","doi":"10.1038/sj.gt.3302081","title":"Widespread distribution of β-hexosaminidase activity in the brain of a Sandhoff mouse model after coinjection of adenoviral vector and mannitol","year":2003,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Sandhoff disease; Viral vector; Biology; Genetic enhancement; Transduction (biophysics); Vector (molecular biology); Gangliosidosis; Molecular biology; Biochemistry; Enzyme; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002617884,0.00113091,0.000583415,0.001610919,0.0004782831,0.0005986794,0.0004201905,0.0007601351,0.001699066],"category_scores_gemma":[0.0001908445,0.000409893,0.0004637524,0.0004229885,0.0010805,0.0008527909,0.0004682977,0.001474992,0.0004365087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004337973,"about_ca_system_score_gemma":0.0004572019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162283,"about_ca_topic_score_gemma":0.00132604,"domain_scores_codex":[0.9997476,0.0000212536,0.0000237021,0.00007891204,0.00004841799,0.00008017705],"domain_scores_gemma":[0.9996448,0.00004953094,0.0001106066,0.00003774092,0.0000318908,0.0001254394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006674312,0.0001137298,0.0001981624,0.0000420224,0.00002794278,0.0008429802,0.00005566835,0.00007826305,0.99668,0.0003109204,0.00007132303,0.0009115931],"study_design_scores_gemma":[0.00007873245,0.0009725605,0.0053638,0.00001601861,0.0001199691,0.003654708,0.0001459616,0.001216221,0.9871083,0.0003726256,0.0009261829,0.00002483058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939208,0.001078849,0.002656849,0.0001557311,0.00009782275,0.00003632822,0.0003508616,0.0001622954,0.001540437],"genre_scores_gemma":[0.9922299,0.001046897,0.001830681,0.00006055501,0.00003220512,0.0000628237,0.0004286491,0.00004890453,0.004259489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699066,"threshold_uncertainty_score":0.005683899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598688719214018,"score_gpt":0.2992854785033272,"score_spread":0.2732985913111871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}