{"id":"W2053378951","doi":"10.1074/jbc.m808920200","title":"Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Alzheimer's Association","keywords":"Palmitoylation; Lipid raft; Raft; Amyloid precursor protein secretase; Cell biology; Amyloid precursor protein; Transmembrane protein; Proteolysis; Biology; Biochemistry; Chemistry; Alzheimer's disease; Cysteine; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502381,0.0002840268,0.000270155,0.000252384,0.000185689,0.0003505116,0.0002002785,0.0002533029,0.0007311667],"category_scores_gemma":[0.0002577755,0.0002825586,0.0002253192,0.0001558713,0.0003089221,0.0002214356,0.0002723719,0.0004354929,0.0002957168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002681914,"about_ca_system_score_gemma":0.0002584153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024654,"about_ca_topic_score_gemma":0.0008424284,"domain_scores_codex":[0.9997856,0.00004077386,0.00004065733,0.00003548502,0.00005327563,0.00004422859],"domain_scores_gemma":[0.9997476,0.00005154166,0.00006064075,0.00004236816,0.00004271487,0.00005521982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013857,0.00001651358,0.0001174763,0.00001243207,0.000004424747,0.00003951858,0.00001469072,0.00001638097,0.9994643,0.00003220081,0.000005854568,0.0001749078],"study_design_scores_gemma":[0.00002195097,0.0002527331,0.003865489,0.00000448391,0.00001782533,0.000368259,0.00003246799,0.0004813239,0.9939652,0.00004273812,0.0009423339,0.000005231235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982609,0.0004363624,0.0006139727,0.00003523453,0.00001294926,0.00001854636,0.0001350773,0.00001573182,0.0004712294],"genre_scores_gemma":[0.9965733,0.0005201945,0.001006431,0.00003090003,0.000008369827,0.00003965289,0.0004721911,0.00001483694,0.001334198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024654,"threshold_uncertainty_score":0.002445996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05377894673960478,"score_gpt":0.3180926559845142,"score_spread":0.2643137092449095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}