{"id":"W2053420373","doi":"10.1182/blood-2014-05-576470","title":"Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"Cancer Council NSW; National Health and Medical Research Council; Medical Research Council; University of North Carolina at Chapel Hill; University of New South Wales","keywords":"Apoptosis; Lymphoblastic Leukemia; Glucocorticoid; Cancer research; Medicine; Leukemia; Acute lymphocytic leukemia; Venetoclax; Immunology; Internal medicine; Biology; Chronic lymphocytic leukemia; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007887367,0.0001249198,0.0001594212,0.0001451487,0.0001153786,0.0002941912,0.0001026858,0.00007930719,0.0007258277],"category_scores_gemma":[0.00008242152,0.000079265,0.00008939271,0.0001647905,0.0001239557,0.0001338754,0.0001711467,0.0002457802,0.0001977191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352824,"about_ca_system_score_gemma":0.0001656152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212477,"about_ca_topic_score_gemma":0.0009139063,"domain_scores_codex":[0.9998741,0.00002485827,0.000007975382,0.00002301893,0.00004142041,0.00002852493],"domain_scores_gemma":[0.9999477,0.000007966466,0.00001583653,0.000005787967,0.000008825275,0.00001392192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117139,0.00001150984,0.0008208966,0.0000141064,0.000003108686,0.00002621402,0.00002299917,0.00004817461,0.9972879,0.0001025741,0.00002911221,0.001516375],"study_design_scores_gemma":[0.00002670191,0.0002459774,0.04321216,0.000005409065,0.00001933401,0.0003406903,0.0001663497,0.0009866962,0.9506893,0.00007931912,0.004223017,0.000005032805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965796,0.001233492,0.001233611,0.0000356813,0.000007321492,0.000006931136,0.0002483732,0.00002964568,0.0006253488],"genre_scores_gemma":[0.9977869,0.0005395018,0.0006048253,0.00002233253,0.000002937587,0.00001331036,0.0003271467,0.000006432934,0.0006966721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007258277,"threshold_uncertainty_score":0.002432585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005710001004678429,"score_gpt":0.2036176854776369,"score_spread":0.1979076844729585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}