{"id":"W2053450751","doi":"10.1067/mjd.2002.126823","title":"Drug interactions: Proteins, pumps, and P-450s","year":2002,"lang":"en","type":"review","venue":"Journal of the American Academy of Dermatology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Computational biology; Drug; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005520877,0.0004692642,0.002867193,0.0004697151,0.0001586389,0.00001338567,0.001187431,0.0002807862,0.0001883705],"category_scores_gemma":[0.0001739866,0.0003069042,0.0008376888,0.0005132369,0.001219862,0.000111253,0.0003506902,0.003910085,0.00003021762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005781271,"about_ca_system_score_gemma":0.0001735617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006569484,"about_ca_topic_score_gemma":6.709632e-7,"domain_scores_codex":[0.9949167,0.002327976,0.001790869,0.000263117,0.000265616,0.0004357536],"domain_scores_gemma":[0.992976,0.000881173,0.00559397,0.0001820722,0.00008905608,0.0002778056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007115149,0.0002085078,0.0001593118,0.002092084,0.001295241,0.00005397431,0.0001668979,0.000006278192,0.0002065998,0.0002033398,0.01922402,0.9763126],"study_design_scores_gemma":[0.0005183621,0.00002330937,0.00003614865,0.0008700455,0.002706227,0.01096626,0.0000338802,0.00004147359,0.0006011124,0.0002618172,0.9836858,0.0002555664],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00256602,0.9902944,0.000007025689,0.004902973,0.001215051,0.0005414425,0.00007438169,0.00001091428,0.0003878161],"genre_scores_gemma":[0.003223278,0.9936889,0.0003080913,0.001856231,0.000476169,0.00002541924,0.000001413453,0.00005036496,0.0003701158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9760571,"threshold_uncertainty_score":0.9999383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1446874382603087,"score_gpt":0.4860916144772223,"score_spread":0.3414041762169137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}