{"id":"W2053454808","doi":"10.1016/j.ijpharm.2009.01.003","title":"Development and characterization of oral lipid-based Amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans","year":2009,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; BC Cancer Agency; University of British Columbia; British Columbia Institute of Technology","funders":"Natural Sciences and Engineering Research Council of Canada; British Columbia Centre for Disease Control","keywords":"Candida albicans; Aspergillus fumigatus; Amphotericin B; Antifungal drug; Chemistry; Solubility; Dosage form; PEG ratio; Pharmacokinetics; Chromatography; Corpus albicans; Pharmacology; Microbiology; Medicine; Biology; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582636,0.0002301207,0.0001745858,0.0001866729,0.0001176105,0.000180416,0.0001089147,0.0001997569,0.0003362124],"category_scores_gemma":[0.0001754885,0.0001574567,0.0001876773,0.0001080247,0.0001654152,0.0002619739,0.00009056848,0.0003000511,0.0001038385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410149,"about_ca_system_score_gemma":0.0001934819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005865098,"about_ca_topic_score_gemma":0.0005491007,"domain_scores_codex":[0.9999393,0.000008486466,0.000006365241,0.0000129097,0.00001966931,0.00001329759],"domain_scores_gemma":[0.9999061,0.00001483514,0.00004220435,0.000006552476,0.00001595898,0.00001441897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00012702,0.00003208671,0.00006514395,0.00001760221,0.000001984202,0.00001739824,0.000006411707,0.00005177107,0.9981108,0.00003308407,0.000007257375,0.001529421],"study_design_scores_gemma":[0.00002233611,0.000633134,0.00116886,0.000002364016,0.00001578082,0.00008823504,0.00000828417,0.0003625487,0.9972269,0.00002014641,0.0004482683,0.000003063316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934537,0.0009656419,0.005047449,0.00004216294,0.000008732329,0.00004616469,0.0001296799,0.0000280249,0.0002784721],"genre_scores_gemma":[0.991614,0.0009676801,0.006176051,0.00002517452,0.000006515046,0.00004616431,0.0001684213,0.00001221271,0.0009838459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005865098,"threshold_uncertainty_score":0.001166165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07472989519691771,"score_gpt":0.388324580725728,"score_spread":0.3135946855288103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}